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Ali Akbar Amirzargar¹, Nima Rezaei², Hossein Jabbari³, Abdol-Ali Danesh¹, Farideh Khosravi¹, Mahboubeh Hajabdolbaghi³, Alireza Yalda³, Behrouz Nikbin¹
European Cytokine Network, Vol.17, No.2, pp. 84-89, 2006
Abstract Background. Several genes coding for different cytokines may affect host susceptibility totuberculosis. Methods. In the present study, the allele and genotype frequencies of a number polymorphic genescoding for cytokines or cytokine receptors were investigated in Iranian patients with pulmonary tuberculosis(PTB). Results. From the IL-1 cluster, a positive, significant difference was found at position -889, where the T/Tgenotype was over represented in PTB patients (p = 0.01); a positive, significant increase was found in the IL1RPstI 1970 C/C genotype, where the C allele was over represented in the PTB patients (p = 0.01). A significantnegative association… More >

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ARTICLE

Silvia Stojanov^1,*, Florian Hoffmann^1,*, Anja Kéry¹, Ellen D. Renner^1,2, Dominik Hartl¹, Peter Lohse³, Kristina Huss¹, Peter Fraunberger³, James D. Malley⁴, Stephanie Zellerer¹, Michael H. Albert¹, Bernd H. Belohradsky¹
European Cytokine Network, Vol.17, No.2, pp. 90-97, 2006
Abstract PFAPA syndrome is characterized by periodic episodes of high fever, aphthous stomatitis, pharyngitis, and/or cervical adenitis. It is of unknown etiology and manifests usually before 5 years of age. We determined serum and intracellular cytokine levels in six PFAPA patients (4 males, 2 females, mean age 8 years (± 1.2 SEM), range 4-13) during the symptom-free period as well as 6-12 hours and 18-24 hours after fever onset. Values were compared to age-matched, healthy controls. Febrile PFAPA attacks led to a significant increase in IL-6 and IFN-γ serum concentrations compared to symptom-free periods and to… More >

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ARTICLE

Ying Gao¹, Hans Tapper², Jero Calafat³, Inge Olsson¹, Markus Hansson¹
European Cytokine Network, Vol.17, No.2, pp. 98-108, 2006
Abstract In this experiment, we explored the potential of secretory lysosomes of hematopoietic cells to act as vehicles for immunomodulatory protein delivery at an inflammation site. We investigated whether exogenous soluble TNF-receptor 1 (sTNFR1) could be expressed in primary hematopoietic progenitor cells and become targeted for storage and secretion during granulopoietic differentiation. An sTNFR1 construct with a transmembrane domain (tm) and a cytosol sorting signal (Y) taken from CD63, was retrovirally transduced to lineage-negative murine hematopoietic bone marrow stem/progenitor cells. This process was followed by cytokine-driven granulopoietic maturation. The sTNFR1-tm-Y was found to be synthesized in… More >

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ORIGINAL ARTICLE

Elena Voronov^1,*, Molly Dayan^2,*, Heidy Zinger², Lubov Gayvoronsky¹, Jian-Ping Lin², Yoichiro Iwakura³, Ron N. Apte^1,**, Edna Mozes^2,**
European Cytokine Network, Vol.17, No.2, pp. 109-116, 2006
Abstract IL-1 is one of the most pleiotropic pro-inflammatory and immunostimulatory cytokines. Overproduction of IL-1 has been shown to be involved in the pathogenicity of various autoimmune inflammatory diseases, including systemic lupus erythematosus (SLE). However, the different contributions that the IL-1 agonistic molecules make in their in vivo native milieu, IL-1β which is mainly secreted against IL-1α which is mainly cell-associated, have not been established. Experimental SLE can be induced in mice by injection with monoclonal anti-DNA antibodies bearing a major idiotype designated, 16/6Id. In the present study, experimental SLE was induced in mice deficient in… More >

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ARTICLE

Danielle Gomez-Merino¹, Catherine Drogou¹, Charles Yannick Guezennec¹, Pascal Burnat², Cyprien Bourrilhon¹, Armand Tomaszewski³, Stéphane Milhau⁴, Mounir Chennaoui¹
European Cytokine Network, Vol.17, No.2, pp. 117-124, 2006
Abstract Suggested mechanisms for the systemic, circulating cytokinemia observed during heavy physical exertion include inflammation and energy demand. We compared cytokine levels and examined the underlying physiological mechanisms between a long-distance triathlon and a 100-km run, two endurance races of similar duration but characterized by differences in muscle strain. Blood samples were collected from 12 triathletes (34.8 ± 1.4 yr) and 11 runners (42.4 ± 2.2 yr) the day before and at the end of races (T1, R1), and 24 h and 7 days post-race (R2, R3). At R1, significant race-related differences were observed, with greater… More >

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ARTICLE

Carolina Figueroa¹, Alexis Peralta², Luisa Herrera³, Pedro Castro², Andrea Gutiérrez², Jorge Valenzuela^1,4, Juan C. Aguillón², Rodrigo Quera^1,4, Marcela A. Hermoso²
European Cytokine Network, Vol.17, No.2, pp. 125-130, 2006
Abstract Crohn’s disease (CD) and ulcerative colitis (UC) are multifactorial diseases with a genetic background. Genes related to the innate immune response have been observed to be involved. Polymorphisms of Toll-like receptor 4 (TLR4) and CARD15/NOD2 are thought to be involved in the pathogenesis of inflammatory bowel disease (IBD). There is no information about the frequency of these polymorphisms in South American and Chilean populations. Aim. To investigate the distribution of CARD15/NOD2 (Arg702Trp, Gly908Arg and Leu1007fsinsC) and TLR4 (Asp299Gly) polymorphisms in Chilean patients with IBD. Methods. DNA was obtained from 22 CD, 22 UC patients and… More >

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ARTICLE

Carita Eklund¹, Arja Nenonen^2,3,4, Katriina Kukkonen-Harjula³, Patrik Borg³, Mikael Fogelholm^3,5, Seppo Laine⁶, Heini Huhtala⁷, Terho Lehtimäki⁴, Mikko Hurme^1,8
European Cytokine Network, Vol.17, No.2, pp. 131-135, 2006
Abstract Elevated plasma concentration of C-reactive protein has emerged as an important predictor of future cardiovascular diseases and metabolic abnormalities in apparently healthy individuals. Obese individuals tend to have elevated C-reactive protein concentrations. Weight loss induces a change in this protein, and single nucleotide polymorphisms in regulating genes might affect this change, since C-reactive protein concentration is known to be approximately 40-50% heritable. Our aim was to study the association between the IL6 -174(G/C), IL1B +3954(C/T) and CRP +1059(G/C) single nucleotide polymorphisms, and CRP concentrations in obese men during a weight reduction program. We genotyped 72… More >

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ARTICLE

Thomas Makris, Georgios Stavroulakis, Demetrios Papadopoulos, Ioannis Paizis, Panagiota Krespi, Caterina Tsoukala, Antonios Hatzizacharias, Vasilios Votteas
European Cytokine Network, Vol.17, No.2, pp. 137-141, 2006
Abstract White coat hypertension (WCH) or isolated clinic hypertension is generally accepted to be a benign condition, although some reports have suggested that it may be associated with an increased cardiovascular event rate or other cardiovascular alterations. It has been previously shown that essential hypertension (EH) is associated with abnormalities in haemostatic/fibrinolytic balance and endothelial function. The aim of our study was to assess the impact of WCH on fibrinolytic balance and endothelial function by measuring plasma levels of plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator antigen (tPA), fibrinogen, and thrombomodulin. These markers were determined in More >

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NOTICE OF REDUNDANT PUBLICATION

Didier Fradelizi, Jacques Bertoglio, Vincent Praloran, Mireille Viguier
European Cytokine Network, Vol.17, No.2, pp. 143-143, 2006
Abstract This article has no abstract. More >

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