Anti-inflammatory action and effects on carbohydrate and lipid metabolism: an understudied role of interleukin-6
Francisco Javier Alarcón-Aguilar, Israel Domínguez de la Mora, Angeles Fortis-Barrera
European Cytokine Network, Vol.35, No.4, pp. 48-55, 2024, DOI:10.1684/ecn.2024.0499
Abstract Interleukin-6 (IL-6) is a cytokine with pleiotropic effects that plays a significant role in the transition from the innate immune response to adaptive response. IL-6 is of interest due to its proinflammatory action, however, it also exhibits anti-inflammatory effects, supporting metabolism and suppressing associated diseases, such as obesity, diabetes mellitus and metabolic syndrome. The IL-6 receptor (IL-6R) is a type I transmembrane glycoprotein in the plasma membrane of only some cell types, such as macrophages, neutrophils, hepatocytes, and T cells. The function of IL-6R requires another transmembrane glycoprotein of 130 kDa (gp130) which, in contrast… More >
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