Open Access

ORIGINAL ARTICLE

Xin Zhang¹, He Nan¹, Jialong Guo¹, Jinyu Liu²
European Cytokine Network, Vol.32, No.2, pp. 15-22, 2021, DOI:10.1684/ecn.2021.0465
Abstract Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by abnormal synovial hyperplasia and the release of inflammatory cytokines. NLRP12 is a member of the family nod-like receptor (NLR) families that are activators of inflammation. However, the role of NLRP12 in fibroblast-like synoviocytes (FLSs) is still unclear. In the present study, we have investigated the role of NLRP12 in fibroblast-like synoviocytes (FLSs). The results demonstrated that NLRP12 overexpression inhibited proliferation and promoted cell apoptosis in RA-FLSs. Moreover, NLRP12 overexpression repressed inflammation by downregulation of IL-1β, TNF-α, IL-6, IFN-γ and MCP-1 production and upregulation of More >

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Open Access

ORIGINAL ARTICLE

Francisca Sosa-Jurado¹, Laura Sa´nchez-Reza², Miguel A´ ngel Mendoza-Torres^2,3, Daniel Mele´ndez-Mena^3,4, V´ıctor Hugo Garc´ıa y Garc´ıa², Belinda Guzma´n-Flores⁵, Jose´ Antonio Enciso-Moreno⁶, Juan Ernesto Lo´pez-Ramos^6,7, Juan Carlos Balandra´n⁸, Vero´nica Vallejo-Ruiz¹, Paulina Cortes-Herna´ndez⁹, Julio Reyes-Leyva¹, Gerardo Santos-Lo´pez¹
European Cytokine Network, Vol.32, No.2, pp. 23-30, 2021, DOI:10.1684/ecn.2021.0466
Abstract Chronic hepatitis B (CHB) is classified into five phases based on virus-host interactions: immune tolerance, immune clearance, inactive carrier state, reactive phase and occult hepatitis B infection (OBI). OBI is an uncommon asymptomatic phase of CHB that can be reactivated when the immune system is compromised, occasionally giving rise to severe liver disease. Host immune factors play essential roles in all phases of the CHB infection. Cytokines may alter infection course, influencing the propensity for and the progression of CHB and thus warrant study. Three clinical groups were studied: 48 healthy individuals (HI), 28 patients… More >

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ORIGINAL ARTICLE

Sinan Saral¹, Faruk Saydam², Eda Dokumacioglu³, Mehtap Atak⁴, Levent Tu¨mkaya⁵, Hu¨seyin Avni Uydu⁴
European Cytokine Network, Vol.32, No.2, pp. 31-38, 2021, DOI:10.1684/ecn.2021.0467
Abstract Background: Obesity and dyslipidemia due to estrogen deficiency are among the important health problems in menopausal women. Increasing evidence reports the anti-obesity and anti-hyperlipidemic properties of tea polyphenols. However, the effect of white tea (WT) with high polyphenol content on overweight and lipid profile is uncertain. Here, we aimed to examine the effects of long-term WT consumption on serum leptin, tumor necrosis factor-alpha (TNF-α) and uncoupling protein 1 (UCP1) mRNA gene expression in ovariectomized (OVX) rats. Methods: Adult rats were divided into four groups (n = 8): (i) sham, (ii) OVX, (iii) WT and (iv)… More >

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Open Access

ORIGINAL ARTICLE

Qingzhu Song¹, Fenglan Zhang², Tian Yuan², Yulong Wei²
European Cytokine Network, Vol.32, No.2, pp. 39-47, 2021, DOI:10.1684/ecn.2021.0468
Abstract Breast cancer is by far the most common malignancy found in women and causes a significant public health problem around the world. Early diagnosis of cancer plays an important role in successful treatment and survival of patients. This study aims to investigate the possibility of plasma Tie2 to be used as a biomarker for diagnosis of breast cancer. In total, 20 healthy volunteers and 33 breast cancer patients were considered for this study. The level of Tie2 in plasma was detected using the ELISA technique and immunohistochemistry was performed to measure the expression of Tie2… More >

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