Open Access

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Mahsa Keshavarz-Fathi^1,2,3, Golshid Sanati^3,4,5, Maryam Sadr³, Bahareh Mohebbi³, Vahid Ziaee^6,7, Nima Rezaei^3,5,8
European Cytokine Network, Vol.32, No.3, pp. 48-54, 2021, DOI:10.1684/ecn.2021.0469
Abstract Cytokine dysregulation is one of the important hallmarks of systemic lupus erythematosus (SLE) in both pediatric and adult patients. Owing to the substantial role of Janus kinase (JAK) and suppressor of cytokine signaling (SOCS) in cytokine signaling, we compared the methylation status of the promoter of JAK2 and SOCS3 between patients with JSLE and healthy controls. Methods: Peripheral blood samples were obtained from patients with JSLE and healthy controls. The promoter methylation was assessed by using the bisulfite conversion system and real-time quantitative multiplex methylation-specific PCR (QM-MSP). Results: The methylation assessments were performed on the… More >

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Open Access

ARTICLE

Shereen A. Baioumy¹, Dina E. Sallam², Shaimaa A. Abdalgeleel³, Shaimaa H. Fouad⁴, Ahmed S. Khedr⁵, Sara I. Taha⁶
European Cytokine Network, Vol.32, No.3, pp. 55-63, 2021, DOI:10.1684/ecn.2021.0470
Abstract Background: Atopic dermatitis (AD) is a common skin disorder accompanied by skin barrier disruption. Patients with AD are commonly affected by food allergy. Objectives: The present case–control study aimed to assess interleukin-17A (IL-17A) serum levels in children with AD and food allergies and to determine whether increased serum levels of this inflammatory cytokine correlate with disease severity. Methods: Healthy control subjects and patients were tested for food allergen reactivity by skin prick test and specific, as well as total, immunoglobulin E (IgE) analysis. IL-17A serum levels were measured by enzyme-linked immunosorbent assay technique. Results: Patients… More >

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