Open Access

REVIEW

Maryam Esmailbeig¹, Abbas Ghaderi^1,2
European Cytokine Network, Vol.28, No.4, pp. 127-140, 2017, DOI:10.1684/ecn.2018.0401
Abstract Interleukin (IL)-18, structurally similar to IL-1β, is a member of IL-1 superfamily of cytokines. This cytokine, which is expressed by many human lymphoid and nonlymphoid cells, has an important role in inflammatory processes. The main function of IL-18 is mediated through induction of interferon-γ (IFN-γ) secretion from T helper (Th1) cells. This cytokine synergistically with IL-12 contributes to Th1 differentiation and, therefore, is important in host defense mechanisms against intracellular bacteria, viruses, and fungi. Recent evidences showing the involvement of IL-18 in Th2 differentiation and ultimately IgE production from B cells have shed a new… More >

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Open Access

REVIEW

Yaelle Elfassy^1,2,a, Chloe McAvoy^2,a, Soraya Fellahi^2,3, Joëlle Dupont⁴, Bruno Fève^2,5, Rachel Levy^1,2, Jean-Philippe Bastard^2,3
European Cytokine Network, Vol.28, No.4, pp. 141-150, 2017, DOI:10.1684/ecn.2018.0403
Abstract Infertility, which increased worldwide over the past few decades, has recently been linked to obesity prevalence. Adipokines, produced by adipose tissue, could be the link between obesity and infertility. The association between circulating adipokines and female infertility has been extensively studied in the last ten years. However, the male aspect has been less investigated, although some adipokines are present in seminal plasma. We have attempted to analyze published studies that measured seminal plasma adipokines and their relationships with semen parameters. Apart from leptin, other seminal adipokines have rarely been studied. Indeed, leptin seems to have More >

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ARTICLE

Nataša Todorović-Raković, Marko Radulovic, Tijana Vujasinović, Jelena Milovanović, Dragica Nikolic-Vukosavljević
European Cytokine Network, Vol.28, No.4, pp. 151-156, 2017, DOI:10.1684/ecn.2018.0402
Abstract There is increasing evidence for the importance of immunity in breast cancer. IFNγ is expected to have a prognostic value based on its major role in innate and specific cell-mediated immunity. In this retrospective study, based on the 14-year follow-up of 73 patients with breast cancer after surgery and radiotherapy but no subsequent systemic therapy, we investigated the prognostic time dependence of intra-tumoural IFNγ mRNA and protein levels. Over the entire 14 years of follow-up, neither IFNγ mRNA nor protein was significantly associated with metastasis outcome by AUC and Cox regression criteria. However, evaluation of… More >

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