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Hala S. Bayomi, Nehal M. Elsherbiny, Amal M. El-Gayar, Mohammed M. H. Al-Gayyar
European Cytokine Network, Vol.24, No.4, pp. 139-147, 2013, DOI:10.1684/ecn.2014.0344
Abstract Purpose: The use of cisplatin, the first of the platinum-containing anti-cancer drugs, is limited by the development of a myriad of adverse reactions, including nephrotoxicity. We conducted this study therefore to find out whether SB-431542, potent and specific inhibitor of type I transforming growth factor-beta receptor (TGF-βR1), could prevent or attenuate kidney damage in rats, and to elucidate its possible mechanism of action. Methods: Fifty rats were treated with cisplatin (10 mg/kg) in the presence (1 and 3 mg/kg) or absence of SB-431542. Morphological changes were assessed in kidney sections stained with H/E. Oxidative stress… More >

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ARTICLE

Randeep S. Jawa¹, Erin Quist², Craig W. Boyer³, Valerie K. Shostrom⁴, David W. Mercer⁵
European Cytokine Network, Vol.24, No.4, pp. 148-156, 2013, DOI:10.1684/ecn.2014.0345
Abstract Introduction: Trauma patients who develop multi-organ dysfunction have increased systemic levels of chemotactic cytokines. Ischemia-reperfusion (IR) injury to the gut may play a role. The purpose of this study was to examine chemokine production in a mouse model of mesenteric IR injury. Given the pre-eminent role of the neutrophil, there has been much investigation of the CXC chemokines, but very limited research on the CC and XC chemokines. We hypothesized that intestinal IR injury would induce remote organ injury and enhance serum CC and XC chemokine levels. Methods: Fasted female C57BL6 mice were anesthetized prior… More >

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Victoria Perna¹, Antonio Pérez-Pérez¹, Patricia Fernández-Riejos¹, Juan Polo-Padillo², Nínive Batista³, Angel Domínguez-Castellano³, Víctor Sánchez-Margalet¹
European Cytokine Network, Vol.24, No.4, pp. 157-161, 2013, DOI:10.1684/ecn.2014.0346
Abstract An impaired immune response in tuberculosis patients seems to be related to weight loss that coexists with an immunoendocrine imbalance. Thus, wasting is well-recognised as a prominent feature of tuberculosis (TB), which may not be reversed even after six months of treatment. Adipokines may play a role in the immune response to M. tuberculosis, and TB may impair the expression of inflammatory adipokines, such as leptin. We aimed to study patients with pulmonary TB before and six months after treatment, by measuring plasma leptin, soluble leptin receptor and adiponectin, weight and body mass index. Nineteen patients… More >

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