Obesity and inflammation
Jacek Karczewski1, Ewelina Śledzi´ nska2, Alina Baturo2, Izabela Jończyk3, Aleksander Maleszko3, Paweł Samborski2, Beata Begier-Krasińska4, Agnieszka Dobrowolska2
European Cytokine Network, Vol.29, No.3, pp. 83-94, 2018, DOI:10.1684/ecn.2018.0415
Abstract The prevalence of obesity has recently increased dramatically and has contributed to the increasing
prevalence of various pathological conditions, including type 2 diabetes mellitus, nonalcoholic fatty liver disease,
asthma, various types of cancer, cardiovascular and neurodegenerative diseases, and others. Accumulating evidence
points to localized inflammation in adipose tissue, which, in turn, promotes systemic low-grade inflammation as
a primary force contributing to the development of these pathologies. A better understanding of the underlying
mechanisms behind obesity-induced adipose tissue inflammation is required to develop effective therapeutic or
prophylactic strategies. This review is aimed to present the current More >
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