Open Access

REVIEW

Obesity and inflammation

Jacek Karczewski¹, Ewelina Śledzi´ nska², Alina Baturo², Izabela Jończyk³, Aleksander Maleszko³, Paweł Samborski², Beata Begier-Krasińska⁴, Agnieszka Dobrowolska²

1 Department of Environmental Medicine/Department of Gastroenterology, Human Nutrition and Internal Medicine, Poznan University of Medical Sciences, Fredry 10, Poznan 61-701, Poland
2 Department of Gastroenterology, Human Nutrition and Internal Medicine, Poznan University of Medical Sciences, Fredry 10, Poznan 61-701, Poland
3 AI Centrum Medyczne, Swietojanska 1, Poznan61-113, Poland
4 Department of Hypertensiology, Angiology and Internal Medicine, Poznan University of Medical Sciences, Fredry 10, Poznan 61-701, Poland

European Cytokine Network 2018, 29(3), 83-94. https://doi.org/10.1684/ecn.2018.0415

Accepted 18 September 2018;

Abstract

The prevalence of obesity has recently increased dramatically and has contributed to the increasing prevalence of various pathological conditions, including type 2 diabetes mellitus, nonalcoholic fatty liver disease, asthma, various types of cancer, cardiovascular and neurodegenerative diseases, and others. Accumulating evidence points to localized inflammation in adipose tissue, which, in turn, promotes systemic low-grade inflammation as a primary force contributing to the development of these pathologies. A better understanding of the underlying mechanisms behind obesity-induced adipose tissue inflammation is required to develop effective therapeutic or prophylactic strategies. This review is aimed to present the current knowledge of adipose tissue inflammation associated with obesity.

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Keywords

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