Study of interferon-stimulated gene 15 expression in the medulloblastoma context
Eva G. Palacios-Serrato1, Karen Medina-Abreu1, Gabriela Velasco-Loyden2, Norma Angélica Lira-Rodríguez1, Angeles C. Tecalco-Cruz1,*
European Cytokine Network, Vol.36, No.4, pp. 64-73, 2025, DOI:10.1684/ecn.2025.0506
Abstract Background: Interferon-stimulated gene 15 (ISG15) is a small ubiquitin-like protein that can be conjugated to its target proteins through an enzymatic cascade known as ISGylation, thereby altering their function. Elevated levels of free ISG15 (non-conjugated) and ISGylation are observed in several cancer types, including medulloblastoma (MB) a malignant pediatric cerebellar tumor categorized into four molecular subgroups: Wingless, Sonic Hedgehog, Subgroup 3 (G3), and Subgroup 4 (G4). However, ISG15 gene expression in MB remains unexplored. In this study, we evaluated the ISG15 protein levels, the expression of the ISG15 and ISGylation system, and interferon gamma signaling… More >
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