Open Access

ARTICLE

Pablo Ramon Gualberto Cardoso¹, Emerson Vasconcelos de Andrade Lima^1,2, Mariana Modesto de Andrade Lima¹, Moacyr Jesus Barreto de Melo Rêgo², Claudia Diniz Lopes Marques², Ivan da Rocha Pitta¹, Angela Luzia Branco Pinto Duarte¹, Maira Galdino da Rocha Pitta¹
European Cytokine Network, Vol.27, No.1, pp. 1-5, 2016, DOI:10.1684/ecn.2016.0371
Abstract Objective and Design: Psoriasis is a common, enigmatic, and recurrent disease. The precise etiology and pathogenesis of psoriasis are still unclear. Psoriasis has been treated as an inflammatory disorder related to an underlying Th1/Th17-dominated immune response. Interleukins are involved in the development of psoriasis lesions through Th-17-associated inflammation. Th1 and Th17 cytokines are found in skin lesions and in the peripheral blood of psoriasis patients. We sought to analyze serum levels of IL-1-β, IL-8, IL-9, IL-27, IL-29, IL-35, IFN-γ, TNF and TGF-β in patients with psoriasis and healthy control volunteers. Material: Blood samples were collected More >

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ARTICLE

Mehyar Mohammad Alsheblak¹, Nehal M. Elsherbiny¹, Amro El-Karef², Mamdouh M. El-Shishtawy¹
European Cytokine Network, Vol.27, No.1, pp. 6-15, 2016, DOI:10.1684/ecn.2016.0372
Abstract The present study was undertaken to investigate the possible protective effect of L-carnosine (CAR), an endogenous dipeptide of alanine and histidine, on carbon tetrachloride (CCl₄)-induced hepatic injury. Liver injury was induced in male Sprague-Dawley rats by intraperitoneal (i.p.) injections of CCl₄, twice weekly for six weeks. CAR was administered to rats daily, at dose of 250 mg/kg, i.p. At the end of six weeks, blood and liver tissue specimens were collected. Results show that CAR treatment attenuated the hepatic morphological changes, necroinflammation and fibrosis induced by CCl₄, as indicated by hepatic histopathology scoring. In addition, CAR treatment… More >

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