Open Access

ARTICLE

Zhenlu Li^#, Chao Yue^#, Shengzhong Hou, Xing Huang, Zihe Wang, Weiming Hu, Huimin Lu^*
European Cytokine Network, Vol.35, No.3, pp. 28-37, 2024, DOI:10.1684/ ecn.2024.0495
Abstract Pancreatic cancer (PC) is one of the leading causes of cancer deaths, associated with a high risk of metastasis and mortality. The long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is highly expressed in multiple types of tumour tissues and may be associated with the growth of PC cells. In this study, we aimed to assess the role and possible mechanisms of MALAT1 in PC progression. Methods: Expression of MALAT1 was studied by quantitative real-time polymerase chain reaction (qRT-PCR) in PC tissues. The dual-luciferase assay was performed to validate binding between MALAT1 and miR-141-5p… More >

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REVIEW

Małgorzata Gryka-Marton, Anna Grabowska, Dariusz Szukiewicz
European Cytokine Network, Vol.35, No.3, pp. 38-47, 2024, DOI:10.1684/ecn.2024.0498
Abstract The blood-brain barrier (BBB) consists of a unique system of brain microvascular endothelial cells, capillary basement membranes, and terminal branches (“end-feet”) of astrocytes. The BBB’s primary function is to protect the central nervous system from potentially harmful or toxic substances in the bloodstream by selectively controlling the entry of cells and molecules, including nutrients and immune system components. During neuroinflammation, the BBB loses its integrity, resulting in increased permeability, mostly due to the activity of inflammatory cytokines. However, the pathomechanism of structural and functional changes in the BBB caused by individual cytokines is poorly understood.… More >

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