Assessment of an ultra-sensitive IFNγ immunoassay prototype for latent tuberculosis diagnosis
Elyes Ben Salah1, Karim Dorgham1, Mylène Lesénéchal2, Camille Pease2, Laure Allard2, Céline Dragonetti2, Guy Gorochov1, Amélie Guihot1, Delphine Sterlin1
European Cytokine Network, Vol.29, No.4, pp. 136-145, 2018, DOI:10.1684/ecn.2018.0417
Abstract Worldwide there are about 1.7 billion individuals with latent tuberculosis infection (LTBI) and only
5% to 15% will develop active tuberculosis (TB). It is recommended to treat only those most at risk of develop
ing active TB to avoid problems of drug resistance. LTBI diagnosis involves reviewing the individual’s medical
history, physical examination, and biological tests. Interferon gamma release assays (IGRA) can yield “undetermi
nate” or “uncertain” results, which makes clinical management decisions difficult. We assessed an ultra-sensitive
immunoassay prototype based on single molecule array (SiMoA) technology to evaluate its overall performance,
and in particular,… More >
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