Open Access

REVIEW

Anna Michalak-Stoma¹, Aldona Pietrzak¹, Jacek C. Szepietowski², Anna Zalewska-Janowska³, Tomasz Paszkowski⁴, Grazyna Chodorowska˙ ¹
European Cytokine Network, Vol.22, No.4, pp. 160-168, 2011, DOI:10.1684/ecn.2011.0294
Abstract Psoriasis is a chronic genetically determined, erythemato-squamous disease associated with many comorbidities. Evidence from clinical studies and experimental models support the concept that psoriasis is a T cell-mediated inflammatory skin disease and T helper (Th) cells – Th1, Th17 and Th22 – play an important role in the pathogenesis. Th1 cytokines IFNγ, IL-2, as well as Th17 cytokines IL-17A, IL-17F, IL-22, IL-26, and TNFα (Th1 and Th17 cytokine) are increased in serum and lesional skin. IL-22 produced by Th17 and new subset of T helper cells, Th22, is also increased within psoriatic lesions and in More >

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Open Access

ARTICLE

Cane Tulic^1,a, Miodrag Lazic^2,a, Emina Savic^3,a, Dusan Popadic³, Jelena Djukic¹, Dusan Spasic², Milos Markovic³, Zorica Ramic³, Marija Mostarica-Stojkovic³, Vladimir Trajkovic³
European Cytokine Network, Vol.22, No.4, pp. 169-174, 2011, DOI:10.1684/ecn.2011.0292
Abstract The aim of the study was to correlate the preoperative activity of Th1 and Th17 cytokine axes with the development of sepsis after radical cystectomy. The study involved twenty patients with the infiltrative transitional cell carcinoma of the urinary bladder without previous radiotherapy/chemotherapy, who underwent open radical cystectomy with urinary diversion. Preoperative plasma concentrations of Th1 cytokines interleukin 12 (IL-12) and interferon gamma (IFN-γ), and Th17 cytokines IL-23 and IL-17, were measured using ELISA. Preoperative expression of mRNA for IL-12p35, IFN-γ, IL-23p19 and IL-17 was quantified by real-time RT-PCR using mRNA extracted from peripheral blood… More >

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Open Access

ARTICLE

M. Mahmoudi^1,2, A. A. Amirzargar^1,2, A. R. Jamshidi³, E. Farhadi¹, S. Noori⁴, M. Avraee², B. Nazari², M. H. Nicknam^1,2
European Cytokine Network, Vol.22, No.4, pp. 175-180, 2011, DOI:10.1684/ecn.2011.0293
Abstract Objective. Ankylosing spondylitis (AS) is one of the most common causes of inflammatory arthritis, with an estimated prevalence of 0.1-0.9%. Genetic factors have been strongly implicated in its aetiology, and heritability as assessed by twin studies has been estimated to be >90%. HLA- B27 is almost essential for inheritance of AS; it is not merely sufficient for explaining the pattern of familial recurrence of the disease. This study’s purpose is to investigate the association of ankylosing spondylitis with single-nucleotide polymorphisms (SNPs) in the IL-1 family: IL-1a (-889C/T) rs1800587, IL-1b (-511C/T) rs16944, IL-1b (+3962C/T) rs1143634, IL-1R… More >

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Open Access

ARTICLE

Atefeh Golpaie^1,2, Narges Tajik^1,2, Farzad Masoudkabir³, Zohreh Karbaschian¹, Mohammad Talebpour^2,4, Mostafa Hoseini⁵, Mohammad Javad Hosseinzadeh-Attar^1,2
European Cytokine Network, Vol.22, No.4, pp. 181-186, 2011, DOI:10.1684/ecn.2011.0295
Abstract Background. The aims of this study were to evaluate the short-term effects of laparoscopic restrictive bariatric surgery (LRBS) on plasma levels of vaspin and the potential associations of changes in vaspin levels with changes in anthropometric indices, insulin-resistance and dietary intake. Methods. Thirty, severely obese subjects (21 female; mean age, 32.5 years) with a mean body mass index (BMI) of 44.1 ± 4.9 kg/m² underwent LRBS. Measurements of anthropometric indices, dietary intakes, physical activity and plasma vaspin concentrations were performed prior to, and six weeks after LRBS. Insulin-sensitivity was estimated using the homeostasis model assessment of… More >

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