Open Access

REVIEW

Chen Liu^1,a, Juntao Chen^1,a, Baoqing Liu^1,a, Shunzong Yuan^2,a, Dawei Shou³, Liang Wen¹, Xiaoying Wu⁴, Weihua Gong¹
European Cytokine Network, Vol.29, No.2, pp. 48-51, 2018, DOI:10.1684/ecn.2018.0410
Abstract Since pro-inflammatory cytokine IL-18 and its receptor (IL-18R) are closely involved in regulating both adaptive and innate immune responses, it is conceivable that they might play an important role in organ transplantation. IL-18 can stimulate lymphocytes to produce the IFN-γ and regulate macrophage activity, thereby increasing the expression of proinflammatory cytokines including IL-1β, IL-6, CCL4 (macrophage inflammatory protein-1 β), CXCL2 (macrophage inflammatory protein-2), and CCL2 (monocyte chemotactic protein-1). Nevertheless, the IL-18 signaling pathway and its underlying mechanisms remain obscure in transplant biology. This review is to summarize recent advances in our knowledge about the IL-18… More >

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ARTICLE

Faruk Tas, Senem Karabulut, Kayhan Erturk, Derya Duranyildiz
European Cytokine Network, Vol.29, No.2, pp. 52-58, 2018, DOI:10.1684/ecn.2018.0408
Abstract Leptin may support the proliferation and hinder the apoptosis of tumor cells. Although leptin expression has been studied in several human tumors, its potential clinical significance remains uncertain in patients with gastric carcinoma. Furthermore, the majority of available findings have been determined from preclinical studies using stomach carcinoma tissue section and, to date, few studies have evaluated the clinical significance of leptin in the serum or plasma of gastric carcinoma patients. In the current study, the serum concentration of soluble leptin was assessed in gastric carcinoma patients, and its contributions to the clinical parameters and… More >

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ARTICLE

Karinna Chouman¹, Birgit Korioth-Schmitz¹, Markus Sack², Jörn Engelbert Schmitz¹, Anh Tuan Pham¹, Rainer Fischer^2,4, Stefan Barth⁵, Torsten Klockenbring¹, Rolf Fendel^1,6
European Cytokine Network, Vol.29, No.2, pp. 59-72, 2018, DOI:10.1684/ecn.2018.0409
Abstract Interleukin-6 (IL-6) expression and secretion, induced by inflammatory processes, stimulate the acute phase response cascade. The overexpression of IL-6 contributes to a variety of inflammatory diseases, e.g. rheumatoid arthritis, Castleman’s disease, multiple myeloma, and prostate cancer. Screening for high amounts of IL-6 in the patients’ blood serum can be crucial for an adequate treatment. In this study, five novel murine monoclonal antibodies (mAbs) reactive to human IL-6 were generated. The mAbs were characterized for potential diagnostic purposes and recombinant antibodies were derived thereof. Initial epitope mapping using a combination of blocking experiments and Hyper-IL-6, a fusion… More >

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