Open Access
ARTICLE
Jiawen Chen1,#, Zelin Liu1,#, Keke Huang1, Jinlan Li1, Yajie Zhang1, Dandan Chen1, Yanjie Ruan2, Ying Pan1, Furun An1, Yang Wan1,*, Jiyu Wang1,3,*, Qianshan Tao1,*
European Cytokine Network, DOI:10.32604/ecn.2026.077875
Abstract Objectives: B-cell lymphoma exhibits significant clinical heterogeneity, necessitating improved biomarkers for risk stratification. C-C chemokine receptor 7 (CCR7) and trimethylation of histone H3 lysine 9 (H3K9me3) are implicated in cellular senescence and tumor invasion. While the clinical significance of their co-expression in lymphomagenesis remains unclear. This study aims to define the expression profiles of CCR7 and H3K9me3 in B-cell lymphoma, explore their correlation with aggressive clinical indicators, and evaluate their combined prognostic value. Methods: The expression of CCR7 and H3K9me3 in tumor tissues from B-cell lymphoma patients was analyzed by immunohistochemical (IHC) double-staining. The mechanistic… More >
Open Access
REVIEW
Natália Alvarenga Borges1, Larissa Manhães1, Ludmilla Dias de Santana e Santana1, Jessyca Sousa de Brito2, Larissa Fonseca3, Ludmila F. M. F. Cardozo4, Denise Mafra2,3,4,*,#
European Cytokine Network, DOI:10.32604/ecn.2026.0ECN78096
Abstract The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that exhibits antagonistic pleiotropy, mediating both protective and detrimental cellular effects depending on the ligand and context. AhR can be activated by a variety of endogenous and exogenous stimuli, including environmental pollutants, UVB radiation, heme, arachidonic acid metabolites, gut microbiota–derived compounds, and xenobiotics. Upon activation, AhR translocates to the nucleus, where it dimerizes with the aryl hydrocarbon receptor nuclear translocator (ARNT) and binds to xenobiotic response elements, inducing the expression of genes involved in xenobiotic metabolism, oxidative stress responses, and inflammatory signaling. In addition to… More >
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