Open Access

ARTICLE

Ischemic time of graft liver forces Th1-to-Th2 activity toward Th1 activity in patients who underwent living donor liver transplantation

Chul Soo Park¹, Hye Young Moon², Sangbin Han², Jin Young Chon², Min Suk Chae¹, Sang Hyun Hong¹, Jong Ho Choi¹, Hyun Sik Chung¹

1 The Catholic University of Korea, College of Medicine, Seoul St. Mary’s Hospital, Department of Anesthesiology and Pain Medicine, Seoul, Republic of Korea
2 The Catholic University of Korea, College of Medicine, Yeouido St. Mary’s Hospital, Department of Anesthesiology and Pain Medicine, Seoul, Republic of Korea

* Corresponding Author: H. Chung,

European Cytokine Network 2019, 30(1), 23-28. https://doi.org/10.1684/ecn.2019.0422

Accepted 17 January 2019;

Abstract

Recipient’s immune responses are an important factor in allograft survival in transplantation. Cytokines are reflected with immune responses. In the present study, we aimed to evaluate potential affecting factors of liver allograft survival and their possible correlation with seroum cytokine levels in living donor liver transplantation (LDLT). One hundred and seventy-one adult patients’ data were collected retrospectively. Five cytokines were collected: interferon (IFN)-γ, interleukin (IL)-2, IL-10, IL-6, and IL-17. Ischemic time of liver grafts was divided into two periods: cold and warm ischemic times (CIT and WIT, respectively). CIT had no statically significant correlation, but WIT showed a significant correlation with IFN-γ, IL-2, and IL-17 serum levels (r = 0.0252, 0.282, 0.178, respectively; P < 0.05). WIT was dichotomized as T1 (<22 min), T2 (22-70 min), and T3 (>70 min). IFN-γ was significantly increased in T2 and T3 as compared to T1. IL-6 was in T3 compared to T1 and T2. IL-17 was in T3 compared to T1. For the Th1-to-Th2 ratio, IFN-γ/IL-10, IFN-γ/IL-6, and IL-2/IL-10 were significantly different in T2 and T3 as compared to T1, and also in T3 as compared to T2. Th1 cell activities were enhanced with increased WIT. In conclusion, the longer WIT (>70 min) in LDLT is more likely to induce immunological reactions of recipients by leading to a deleterious cytokine balances in favor of an reinforced production of Th1 cytokines.

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