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Effect of the Lipophilic o-Naphthoquinone CG 10-248 on Rat Liver Mitochondria Structure and Function

LIDIA M. LOPEZ*, AMANDA PELLEGRINO DE IRALDI*, PATRICIA H. CARRIZO**, MARTA DUBIN**, ANDRÉS O.M. STOPPANI**

Department of Cell Biology and Neurosciences.
Bienergetics Research Centre, School of Medicine, University of Buenos Aires.

Corresponding Author: Andrés O.M. Stoppani, Centro de Investigaciones Bioenergéticas, Facultad de Medicina, UBA. Paraguay 2155, Piso 16°, (1121) Buenos Aires, ARGENTINA. Tel/Fax: (+54-11) 4508 3680; E-mail: email

BIOCELL 2002, 26(2), 237-245. https://doi.org/10.32604/biocell.2002.26.237

Abstract

CG 10-248 (3,4-dihydro-2,2 dimethyl-9-chloro-2H-naphtho[1,2b]pyran-5,6-dione), a ß-lapachone analogue, modified the ultrastructure of rat liver mitochondria in vitro, in the absence of added oxidizable substrates. The condensed mitochondrial state was replaced by the orthodox or swollen state to a significant degree. The number of modified mitochondria depended on incubation time and quinone concentration, in the 25-100 µM range. Under the same experimental conditions, mitochondrial respiration was uncoupled as indicated by the increase in the rate of succinate oxidation by controlled mitochondria in metabolic state “4” (not in state “3”), and by the activation of latent F0 F1 -ATP synthase. Taking into account structural similarities, the results reported here may be valid for other o-naphthoquinones, such as ß-lapachone.

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LOPEZ, L. M., PELLEGRINO, A., CARRIZO, P. H., DUBIN, M., STOPPANI, A. O. (2002). Effect of the Lipophilic o-Naphthoquinone CG 10-248 on Rat Liver Mitochondria Structure and Function. BIOCELL, 26(2), 237–245. https://doi.org/10.32604/biocell.2002.26.237

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