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Overview of genetic causes of recurrent miscarriage and the diagnostic approach

Tarek A ATIA

Prince Sattam bin Abdulaziz University, College of Applied Medical Sciences, Medical Laboratory Sciences Department,Al-kharj, Saudi Arabia

* Address correspondence to: Tarek A Atia, email

BIOCELL 2019, 43(4), 253-262.


Recurring miscarriage (RM) is a frustrating reproductive complication with variable etiology. Numerous genetic defects have been known to play a crucial role in the etiology of RM. Chromosomal abnormalities are frequently detected, while other genetic defects cannot be diagnosed through routine research, such as cryptic chromosomal anomalies, single nucleotide polymorphism, single-gene defect, and gene copy number variation. Diagnostic laboratories have recently used variable advanced techniques to detect potential genetic abnormalities in couples with RM and/or in products of conception. Here we aim to summarize the known genetic causes of RM, with a focus on the new diagnostic techniques. Knowledge of the genetic profile of miscarriages is important for prognosis and potential counseling planning, as well as the prenatal diagnostic strategy in subsequent pregnancies.


Cite This Article

ATIA, T. A. (2019). Overview of genetic causes of recurrent miscarriage and the diagnostic approach. BIOCELL, 43(4), 253–262.


cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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