Open Access

REVIEW

Role of pyroptotic cell death in the pathogenesis of NASH

Yuguo YI, Jiamin ZHENG, Yang ZHOU, Zhiqin LIU, Dan WENG^*

Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, 210094, China

* Address correspondence to: Dan Weng,

BIOCELL 2020, 44(1), 7-11. https://doi.org/10.32604/biocell.2020.08686

Issue published 01 March 2020

Abstract

Nonalcoholic fatty liver disease (NAFLD) represents a huge threat to public health of the whole world. Around 25% of NAFLD patients will progress to nonalcoholic steatohepatitis (NASH), which has been predicted to be the main reason for liver transplantation in the United States in 2020. Extensive effort has been devoted to investigating the underlying molecular mechanisms of NASH pathogenesis and developing new promising treatments. Recent studies have demonstrated that pyroptosis, an inflammatory programmed cell death mediated by inflammasome and gasdermin-D (GSDMD), is involved in the development and progression of NASH. This review aims to summarize the recent findings regarding the role of pyroptosis and related molecules in the pathogenesis of NASH.

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Citations