Table of Content

Open Access iconOpen Access

ARTICLE

crossmark

Effect of Black Sea bream extracts on cytokine production in lipopolysaccharide-induced inflammation

EUN NA1, MYOUNGWON CHOI2, INDAL PARK2, SUNYOUNG LIM3,*

1 Ocean Science and Technology School, Korea Maritime & Ocean University, Busan, Korea
2 Department of Microbiology, Kosin University College of Medicine, Busan, Korea
3 Division of Marine Bioscience, Korea Maritime & Ocean University, Busan, Korea

* Address correspondence to: Sunyoung Lim, email

BIOCELL 2020, 44(2), 193-199. https://doi.org/10.32604/biocell.2020.08648

Abstract

We investigated the effect of black sea bream extracts on changes in pro-inflammatory and anti-inflammatory cytokines induced by lipopolysaccharide (LPS) in murine splenocytes. The levels of pro-inflammatory cytokines [interleukin (IL)-6, tumor necrosis factor-α (TNF-α), IL-12/IL-23(p40) and IL-17A] and anti-inflammatory cytokines [IL-4, IL-10 and interferon-γ (IFN-γ)] were assessed. Incubation of murine splenocytes with acetone+methylene chloride (A+M) and methanol (MeOH) extracts significantly decreased LPS-induced IL-6, IL-12/IL-23(p40) and IL-17A productions after 6 h incubation (p < 0.05). The A+M and MeOH extracts significantly increased LPS-induced IL-4 and IFN-γ productions at 48 and 72 h incubation (p < 0.05). Treatment with A+M extract resulted in significantly higher IL-10 production in splenocytes after 72 h (p < 0.05). Conclusively, black sea bream extracts were shown to be efficient in falling several pro-inflammatory cytokines while rising anti-inflammatory cytokines. Thus our results suggest that black sea bream extracts selectivity modulate immune events.

Keywords


Cite This Article

APA Style
NA, E., CHOI, M., PARK, I., LIM, S. (2020). Effect of black sea bream extracts on cytokine production in lipopolysaccharide-induced inflammation. BIOCELL, 44(2), 193-199. https://doi.org/10.32604/biocell.2020.08648
Vancouver Style
NA E, CHOI M, PARK I, LIM S. Effect of black sea bream extracts on cytokine production in lipopolysaccharide-induced inflammation. BIOCELL . 2020;44(2):193-199 https://doi.org/10.32604/biocell.2020.08648
IEEE Style
E. NA, M. CHOI, I. PARK, and S. LIM "Effect of Black Sea bream extracts on cytokine production in lipopolysaccharide-induced inflammation," BIOCELL , vol. 44, no. 2, pp. 193-199. 2020. https://doi.org/10.32604/biocell.2020.08648

Citations




cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
  • 2712

    View

  • 1670

    Download

  • 0

    Like

Share Link