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Age-related modifications of macrophages influenced by “inflammageing” in graft vs. host disease

YAQUN HONG1,2, BO WAN3, XIAOFAN LI1,4,*

1 Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Department of Hematology, Fujian Medical University Union Hospital, Fuzhou, 350000, China
2 Union Clinical Medical Colleges, Fujian Medical University, Fuzhou, 350000, China
3 Faculty of Life Sciences and Medicine, King’s College London, London, UK
4 INSERM U1160, Hopital Saint Louis, Université Paris Diderot, Sorbonne Paris Cité, Paris, France

* Address correspondence to: Xiaofan Li, email

BIOCELL 2020, 44(2), 237-246. https://doi.org/10.32604/biocell.2020.08887

Abstract

Most studies focus on the adaptive immune cells in the GVHD pathogenesis, while little is known about innate immune cells in GVHD occurrence and development, especially macrophages. Meanwhile, a higher incidence of graft versus host disease (GVHD) is also found in the elderly patients. Though advances have been made in the modification of macrophages influenced by the inflamm-ageing, there is still no review on the role of macrophages in GVHD and the association between GVHD and the altered macrophages by inflamm-ageing. In this review, we focus on the potential age-related modifications of macrophage in GVHD, which contributes to the change of morbidity and mortality of GVHD. Via literature review, we found that the infiltration of macrophages is associated with GVHD and macrophages are modified in inflamm-ageing state, including the proliferation, migration, phagocytosis, antigen presentation, interaction with other immune cells, and pro-fibrosis. We suppose that altered macrophage functions in inflamm-ageing state contribute to GVHD in elderly patients.

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APA Style
HONG, Y., WAN, B., LI, X. (2020). Age-related modifications of macrophages influenced by “inflammageing” in graft <i>vs.</i> host disease. BIOCELL, 44(2), 237-246. https://doi.org/10.32604/biocell.2020.08887
Vancouver Style
HONG Y, WAN B, LI X. Age-related modifications of macrophages influenced by “inflammageing” in graft <i>vs.</i> host disease. BIOCELL . 2020;44(2):237-246 https://doi.org/10.32604/biocell.2020.08887
IEEE Style
Y. HONG, B. WAN, and X. LI "Age-related modifications of macrophages influenced by “inflammageing” in graft <i>vs.</i> host disease," BIOCELL , vol. 44, no. 2, pp. 237-246. 2020. https://doi.org/10.32604/biocell.2020.08887



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