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Oncolytic adenovirus targeting LASP-1 inhibited renal cell cancer progression

FANGHAO SUN1, WENCHAO ZHAO1, LIANSHENG ZHANG2, HONGGUI MA1, JIAN ZHOU1, YOUGAN CHEN1, JIANQUAN HOU1,*

1 Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China
2 Department of Urology, Soochow University Affiliated Wuxi Ninth Hospital, Wuxi, 214000, China

* Address correspondence to: Jianquan Hou, email

BIOCELL 2020, 44(4), 639-647. https://doi.org/10.32604/biocell.2020.013053

Abstract

Recent studies suggested that LIM and SH3 protein 1 (LASP-1) is a promising therapeutic target for renal cell cancer (RCC). This study aimed to explore the role of LASP-1 in RCC. For this purpose, LASP-1 expression in RCC tissues was analyzed by immunohistochemistry and Western blot analysis. Cell proliferation, migration, invasion, and gene expression were detected by CCK-8 assay, Transwell assay, and Western blot analysis. The results showed that LASP-1 was highly expressed in RCC, and its expression level,t was positively correlated with lymph node metastasis and tumor, nodes, and metastases (TNM) stage. The knockdown of LASP-1 expression significantly inhibited the proliferation of RCC cells, increased the apoptosis rate, and inhibited RCC cell invasion and migration by inhibiting epithelial–mesenchymal transition. We conclude that LASP-1 promotes RCC progression and metastasis and is a promising therapeutic target for RCC.

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APA Style
SUN, F., ZHAO, W., ZHANG, L., MA, H., ZHOU, J. et al. (2020). Oncolytic adenovirus targeting LASP-1 inhibited renal cell cancer progression. BIOCELL, 44(4), 639-647. https://doi.org/10.32604/biocell.2020.013053
Vancouver Style
SUN F, ZHAO W, ZHANG L, MA H, ZHOU J, CHEN Y, et al. Oncolytic adenovirus targeting LASP-1 inhibited renal cell cancer progression. BIOCELL . 2020;44(4):639-647 https://doi.org/10.32604/biocell.2020.013053
IEEE Style
F. SUN et al., “Oncolytic adenovirus targeting LASP-1 inhibited renal cell cancer progression,” BIOCELL , vol. 44, no. 4, pp. 639-647, 2020. https://doi.org/10.32604/biocell.2020.013053

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cc Copyright © 2020 The Author(s). Published by Tech Science Press.
This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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