Vol.44, No.4, 2020, pp.479-485, doi:10.32604/biocell.2020.011675
OPEN ACCESS
REVIEW
Melatonin and its protective role against male reproductive toxicity induced by heavy metals, environmental pollutants, and chemotherapy: A review
  • TIECHENG SUN1,#, LINGLI SONG1,#, JING MA2,#, HONG YU1, SHANJIE ZHOU1, SHUSONG WANG2, LI TIAN1,3,*
1 Reproductive Medical Center, Department of Obstetrics and Gynecology, Peking University International Hospital, Beijing, 102206, China
2 NHC Key Laboratory of Family Planning and Healthy/Key Laboratory of Reproductive Medicine of Hebei Province, Shijiazhuang, 050051, China
3 Reproductive Medicine Centre, Peking University Second Affiliated Hospital, Beijing, 100044, China
* Address correspondence to: Li Tian,
# These authors contributed equally to this work.
Received 23 May 2020; Accepted 19 August 2020; Issue published 24 December 2020
Abstract
Melatonin, as a ubiquitous indoleamine hormone, is synthesized primarily by the pineal gland. It has diverse biological effects through quite complex mechanisms. More recently, studies have focused on the mechanism of melatonin in anti-reproductive toxicity/damage. Since melatonin possesses strong antioxidant and anti-apoptotic properties, researchers have examined its potential role in protecting against male reproductive toxicity/damage, which may be induced by chemotherapy or environmental toxicants and can lead to male infertility. In this article, recent progress regarding the protective effects of melatonin on male reproductive toxicity/damage is reviewed.
Keywords
Melatonin, Membrane receptors, Heavy metal, Environmental toxicant, Anti-reproductive toxicity
Cite This Article
SUN, T., SONG, L., MA, J., YU, H., ZHOU, S. et al. (2020). Melatonin and its protective role against male reproductive toxicity induced by heavy metals, environmental pollutants, and chemotherapy: A review. BIOCELL, 44(4), 479–485.
Citations
This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.