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Melatonin and its protective role against male reproductive toxicity induced by heavy metals, environmental pollutants, and chemotherapy: A review

TIECHENG SUN1,#, LINGLI SONG1,#, JING MA2,#, HONG YU1, SHANJIE ZHOU1, SHUSONG WANG2, LI TIAN1,3,*

1 Reproductive Medical Center, Department of Obstetrics and Gynecology, Peking University International Hospital, Beijing, 102206, China
2 NHC Key Laboratory of Family Planning and Healthy/Key Laboratory of Reproductive Medicine of Hebei Province, Shijiazhuang, 050051, China
3 Reproductive Medicine Centre, Peking University Second Affiliated Hospital, Beijing, 100044, China

* Address correspondence to: Li Tian, email
# These authors contributed equally to this work.

BIOCELL 2020, 44(4), 479-485. https://doi.org/10.32604/biocell.2020.011675

Abstract

Melatonin, as a ubiquitous indoleamine hormone, is synthesized primarily by the pineal gland. It has diverse biological effects through quite complex mechanisms. More recently, studies have focused on the mechanism of melatonin in anti-reproductive toxicity/damage. Since melatonin possesses strong antioxidant and anti-apoptotic properties, researchers have examined its potential role in protecting against male reproductive toxicity/damage, which may be induced by chemotherapy or environmental toxicants and can lead to male infertility. In this article, recent progress regarding the protective effects of melatonin on male reproductive toxicity/damage is reviewed.

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APA Style
SUN, T., SONG, L., MA, J., YU, H., ZHOU, S. et al. (2020). Melatonin and its protective role against male reproductive toxicity induced by heavy metals, environmental pollutants, and chemotherapy: A review. BIOCELL, 44(4), 479-485. https://doi.org/10.32604/biocell.2020.011675
Vancouver Style
SUN T, SONG L, MA J, YU H, ZHOU S, WANG S, et al. Melatonin and its protective role against male reproductive toxicity induced by heavy metals, environmental pollutants, and chemotherapy: A review. BIOCELL . 2020;44(4):479-485 https://doi.org/10.32604/biocell.2020.011675
IEEE Style
T. SUN et al., "Melatonin and its protective role against male reproductive toxicity induced by heavy metals, environmental pollutants, and chemotherapy: A review," BIOCELL , vol. 44, no. 4, pp. 479-485. 2020. https://doi.org/10.32604/biocell.2020.011675

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cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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