Open Access

REVIEW

The bacteriophage mu lysis system–A new mechanism of host lysis?

SAIKAT SAMANTA1,#, ASHISH RANJAN SHARMA2,#, ABINIT SAHA1, MANOJ KUMAR SINGH1, ARPITA DAS1, MANOJIT BHATTACHARYA3, RUDRA PRASAD SAHA1,*, SANG-SOO LEE2,*, CHIRANJIB CHAKRABORTY1,*
1 Department of Biotechnology, School of Life Science & Biotechnology, Adamas University, Kolkata, 700126, India
2 Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, 24252, Korea
3 Department of Zoology, Fakir Mohan University, Balasore, 56020, India
* Address correspondence to: Rudra Prasad Saha, ; Sang-Soo Lee, ; Chiranjib Chakraborty,
# Authors contributed equally
(This article belongs to this Special Issue: Bacteriophage Biology and Biotechnology)

BIOCELL 2021, 45(5), 1175-1186. https://doi.org/10.32604/biocell.2021.015537

Received 25 December 2020; Accepted 28 February 2021; Issue published 12 July 2021

Abstract

Bacteriophages are viruses that infect bacteria and can choose any one of the two alternative pathways for infection, i.e., lysis or lysogeny. Phage lysis is one of the conventional biological processes required to spread infection from one bacterium to another. Our analysis suggests that in the paradigm bacteriophage Mu, six proteins might be involved in host cell lysis. Mu has a broad host range, and Mu-like phages were found in both Gram-negative and Gram-positive bacteria. An analysis of the genomes of Mu and Mu-like phages could be useful in elucidating the lysis mechanism in this group of phages. A detailed review of the various mechanisms of phage lysis and different proteins associated with the process will help researchers understand the phage biology and their life cycle in different bacteria. The recent increase in the number of multidrug-resistant (MDR) strains of bacteria and the usual long-term nature of new drug development has encouraged scientists to look for alternative strategies like phage therapy and the discovery of new lysis mechanisms. Understanding the lysis mechanism in the Mu-like phages could be exploited to develop alternative therapeutics to kill drug-resistant pathogenic bacteria. In this review article, we have analyzed the phage Mu-mediated host lysis system, which is unknown till now, and our analysis indicates a possibility of the existence of a new lysis mechanism operating in Mu.

Keywords

Bacteriophage Mu, Host cell lysis, Endolysin, Holin, Spanin

Cite This Article

SAMANTA, S., SHARMA, A. R., SAHA, A., SINGH, M. K., DAS, A. et al. (2021). The bacteriophage mu lysis system–A new mechanism of host lysis?. BIOCELL, 45(5), 1175–1186.

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This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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