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Isolation, purification and structure elucidation of three new bioactive secondary metabolites from Streptomyces lividans AM

MOHAMMAD EL-METWALLY1,*, MAMDOUH ABDEL-MOGIB2, MANAL ELFEDAWY2, GAAD SOHSAH2, AHMED REZK3, MAHMOUD MOUSTAFA4, MOHAMED SHAABAN5,6

1 Botany and Microbiology Department, Faculty of Science, Damanhour University, Damanhour, 22511, Egypt
2 Chemistry Department, Faculty of Science, Mansoura University, El-Mansoura, 35516, Egypt
3 Bioprocess Development Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), New Borg El-Arab City, Alexandria, 21934, Egypt
4 Biology Department, College of Science, King Khalid University, Abha, 9004, Saudi Arabia
5 Chemistry of Natural Compounds Department, Division of Pharmaceutical Industries, National Research Centre, Dokki-Cairo, 12622, Egypt
6 Organic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, Bielefeld, 33615, Germany

* Address correspondence to: Mohammad El-Metwally, email

BIOCELL 2021, 45(5), 1263-1271. https://doi.org/10.32604/biocell.2021.013198

Abstract

Microorganisms are a huge mine of bioactive metabolites, and actinomycetes are one of the very active groups in this area. In this article, we are concerned about the full taxonomical characterization of Streptomyces lividans AM, isolated from Egyptian soil. This isolate produced three new bioactive metabolites, namely: 1-Nona-decanoyl,4-oleyl disuccinate (1), filoboletic acid; (9Z,11E)-8,13-dihydroxy octadeca-9,11-dienoic acid (2), and sitosteryl-3β-D-glucoside (3). Extensive 1D and 2D NMR and HR-mass spectrometry were used to elucidate the structures of the three compounds. Moreover, ten known compounds were also identified. The antimicrobial activity of the producing organism and newly reported compounds (1–3) was investigated against a selected group of pathogenic microorganisms. A full taxonomical characterization of the strain was described as well.

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APA Style
EL-METWALLY, M., ABDEL-MOGIB, M., ELFEDAWY, M., SOHSAH, G., REZK, A. et al. (2021). Isolation, purification and structure elucidation of three new bioactive secondary metabolites from <i>streptomyces lividans</i> AM. BIOCELL, 45(5), 1263-1271. https://doi.org/10.32604/biocell.2021.013198
Vancouver Style
EL-METWALLY M, ABDEL-MOGIB M, ELFEDAWY M, SOHSAH G, REZK A, MOUSTAFA M, et al. Isolation, purification and structure elucidation of three new bioactive secondary metabolites from <i>streptomyces lividans</i> AM. BIOCELL . 2021;45(5):1263-1271 https://doi.org/10.32604/biocell.2021.013198
IEEE Style
M. EL-METWALLY et al., "Isolation, purification and structure elucidation of three new bioactive secondary metabolites from <i>Streptomyces lividans</i> AM," BIOCELL , vol. 45, no. 5, pp. 1263-1271. 2021. https://doi.org/10.32604/biocell.2021.013198



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