Open Access

REVIEW

Apigenin as a promising myocyte protectant against damage and degradation

XIAO HUANG^1,2,3,#,*, ZHIHAI YU^4,#, LIJUAN NING⁵, YU LEI⁵, XUEFEI ZHANG⁵, ZHUYING WANG^2,*

1 Institute of Cultural and Technological Industry Innovation of Tongren, Tongren, 554300, China
2 School of Sports and Physical Education, Nanjing Normal University, Nanjing, 210046, China
3 School of Physical Education, Guangxi University of Science and Technology, Liuzhou, 545006, China
4 Department of Urology Surgery, Chongqing University Three Gorges Hospital, Chongqing, 404000, China
5 School of Sports and Health Science, Tongren University, Tongren, 554300, China
# These two authors contribute equally to this work

* Corresponding Authors: XIAO HUANG, ; ZHUYING WANG,

BIOCELL 2022, 46(2), 383-388. https://doi.org/10.32604/biocell.2021.015651

Received 01 January 2021; Accepted 23 February 2021; Issue published 20 October 2021

Abstract

Myocytes power the movement of all organs in the body. Damage to and degradation of myocytes causes hypokinesia and muscle-related degenerative diseases. Apigenin, a kind of flavone, is being used to treat many disorders. It exerts a host of different pharmacological activities, such as anti-inflammatory, anti-mutagenic, cardioprotective, and antioxidant effects. Accordingly, apigenin is considered a promising candidate for myocyte protection. In this review, we introduced the characteristics of apigenin. The means of apigenin protection of myocytes as well as the mechanism were summarized and discussed. The protective effects can be classified into proliferation-promoting, anti-inflammatory, atrophy-preventing, metabolism-increasing, and antioxidative effects. Additionally, we provided some outlook on the valuable applications of apigenin in sports medicine, which eagerly require further fundamental research.

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Keywords

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