Open Access

ARTICLE

KIAA1199 induces advanced biological behavior and development of ovarian cancer through activation of the IL-6/STAT3 pathway

SHUTING GU^1,2,#, JINGYI QIN^3,#, SAINAN GAO¹, ZHEN WANG^1,4, QI MENG^1,4, YAN LI^1,4, BING LU⁵, SONGLIN ZHOU^1,2,*, YUNZHAO XU^1,6,*
1 Department of Obstetrics and Gynecology, Affiliated Hospital of Nantong University, Nantong, 226001, China
2 Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China
3 Key Laboratory for Nano-Bio Interface Research, Nano-Bio-Chem Centre, Suzhou Institute of Nano-Techand Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123, China
4 Department of Obstetrics and Gynecology, Dalian Medical University, Dalian, 116044, China
5 Department of Clinical Biobank, Affiliated Hospital of Nantong University, Nantong, 226001, China
6 Department of Obstetrics and Gynecology, School of Medicine, Nantong University, Nantong, 226001, China
* Corresponding Authors: SONGLIN ZHOU. Email: ; YUNZHAO XU. Email:

BIOCELL 2022, 46(3), 689-697. https://doi.org/10.32604/biocell.2022.016225

Received 19 February 2021; Accepted 24 May 2021; Issue published 18 November 2021

Abstract

Recently, abnormal expression of KIAA1199 has been detected in Epithelial Ovarian Cancer (EOC). However, the underlined anti-ovarian cancer mechanism of KIAA1199 remains to be enlightened. In our study, we performed to elucidate the effects of KIAA1199 on the advanced biological behavior of EOC cells through activation of the IL-6/STAT3 pathway. Confirmed by immunohistochemistry, KIAA1199 was highly expressed in ovarian borderline and malignant epithelial tumors. A retrospective analysis found that EOC patients with low expression of KIAA1199 had a significantly higher 5-year survival rate than those with high expression. Mechanistically, IL-6 was used to stimulate EOC cells, and the expression of KIAA1199, STAT3 and p-STAT3 increased after IL-6 stimulation. These results could show that KIAA1199 is transcriptionally activated by IL6/STAT3 pathway, thereby accelerating the deterioration of EOC. KIAA1199 could also be used as a poor prognosis factor and potential target in treatment.

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Keywords

Epithelial Ovarian Cancer (EOC); KIAA1199; IL-6/STAT3 pathway; Prognosis

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