Open Access

REVIEW

The role of transcriptional factor brachyury in the development and repair of nucleus pulposus

YINGHUI WU^#, HONG ZHANG^#, QIANG WANG, SUOYUAN LI, JUN SHEN^*

Department of Orthopeadic Surgery, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, 215002, China

*Address correspondence to: Jun Shen,
# These authors contributed equally to this work

(This article belongs to this Special Issue: Cell-Based Regenerative Therapies)

BIOCELL 2022, 46(6), 1363-1364. https://doi.org/10.32604/biocell.2022.018360

Received 19 June 2021; Accepted 02 September 2021; Issue published 07 February 2022

Abstract

Transcription factor Brachyury, a protein containing 435 amino acids, has been widely investigated and reported in notochord differentiation and nucleus pulposus development. The crucial functions and underlying mechanisms by Brachyury are discussed in this paper, which suggests Brachyury can be developed into a potential novel target for the therapy of intervertebral disc degeneration.

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Keywords

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