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A need for stratification of metastasis samples according to secondary site in gene expression studies
IVANA SAMARŽIJA1,2,*
1 Laboratory for Epigenomics, Division of Molecular Medicine, Ruđer Bošković Institute, Zagreb, 10000, Croatia
2 Laboratory for Cell Biology and Signaling, Division of Molecular Biology, Ruđer Bošković Institute, Zagreb, 10000, Croatia
* Corresponding Author: Ivana Samaržija,
BIOCELL 2022, 46(7), 1747-1750. https://doi.org/10.32604/biocell.2022.018784
Received 17 August 2021; Accepted 18 October 2021; Issue published 17 March 2022
Abstract
Comparisons of gene expression profiles between primary tumors and metastasis have revealed genes that are
implicated in metastasis formation. However, gene expression studies conducted on metastasis samples from the same
primary site usually do not discriminate between different secondary sites. Although the change in the expression of
number of genes is expected to be common to metastasis from the same primary but different secondary sites, herein
the data that point to substantial differences are presented. Furthermore, the reciprocal communication between
metastatic and host cells that is influencing these differences is outlined to emphasize the need for stratification of
metastasis samples in gene expression studies.
Keywords
Cite This Article
SAMARŽIJA, I. (2022). A need for stratification of metastasis samples according to secondary site in gene expression studies.
BIOCELL, 46(7), 1747–1750.