Open Access

ARTICLE

Candidate oncogene placenta specific 8 affects cell growth and cell migration in non-small cell lung cancers

JINNI MA^#, MEILIN ZHOU^#, XIN XU, XINYAO GAO, HAIXIA WANG, JINHUA SHEN, LU XUE^*

Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South-Central Minzu University, Wuhan, 430074, China

* Corresponding Author: LU XUE. Email:

BIOCELL 2024, 48(2), 239-252. https://doi.org/10.32604/biocell.2023.045076

Received 16 August 2023; Accepted 30 November 2023; Issue published 23 February 2024

Abstract

Background: Placenta specific 8 (PLAC8) is a candidate oncogene involved in the development and progression of solid tumors. However, the status of PLAC8 in lung cancer (LC), especially non-small cell lung cancer (NSCLC) is still not lucid. Methods: Tissue microarray analysis (TMA) was performed to detect the expression patterns of PLAC8 in LC tissues and cell lines. Then a series of cellular experiments were performed fto assess cell proliferation, cell cycle profiles, and cell motility to explore the role of PLAC8 in NSCLC-derived cell lines: H1299 and A549. Results: TMA results showed that PLAC8 played complex and even contradictory roles in different LC samples. Detailed cell-based experiments confirmed that PLAC8 could promote cell viability, alter the cell cycle, and accelerate cell mobility by regulating cell cyclins or cadherins, respectively. Conclusions: The study findings indicate that PLAC8 might participate in LC, especially NSCLC, by affecting cellular physiological processes. The outcomes also shed new light on the potential role of PLAC8 as a therapeutic biomarker in NSCLC.

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