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Candidate oncogene placenta specific 8 affects cell growth and cell migration in non-small cell lung cancers

JINNI MA#, MEILIN ZHOU#, XIN XU, XINYAO GAO, HAIXIA WANG, JINHUA SHEN, LU XUE*

Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South-Central Minzu University, Wuhan, 430074, China

* Corresponding Author: LU XUE. Email: email

BIOCELL 2024, 48(2), 239-252. https://doi.org/10.32604/biocell.2023.045076

Abstract

Background: Placenta specific 8 (PLAC8) is a candidate oncogene involved in the development and progression of solid tumors. However, the status of PLAC8 in lung cancer (LC), especially non-small cell lung cancer (NSCLC) is still not lucid. Methods: Tissue microarray analysis (TMA) was performed to detect the expression patterns of PLAC8 in LC tissues and cell lines. Then a series of cellular experiments were performed fto assess cell proliferation, cell cycle profiles, and cell motility to explore the role of PLAC8 in NSCLC-derived cell lines: H1299 and A549. Results: TMA results showed that PLAC8 played complex and even contradictory roles in different LC samples. Detailed cell-based experiments confirmed that PLAC8 could promote cell viability, alter the cell cycle, and accelerate cell mobility by regulating cell cyclins or cadherins, respectively. Conclusions: The study findings indicate that PLAC8 might participate in LC, especially NSCLC, by affecting cellular physiological processes. The outcomes also shed new light on the potential role of PLAC8 as a therapeutic biomarker in NSCLC.

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APA Style
MA, J., ZHOU, M., XU, X., GAO, X., WANG, H. et al. (2024). Candidate oncogene placenta specific 8 affects cell growth and cell migration in non-small cell lung cancers. BIOCELL, 48(2), 239-252. https://doi.org/10.32604/biocell.2023.045076
Vancouver Style
MA J, ZHOU M, XU X, GAO X, WANG H, SHEN J, et al. Candidate oncogene placenta specific 8 affects cell growth and cell migration in non-small cell lung cancers. BIOCELL . 2024;48(2):239-252 https://doi.org/10.32604/biocell.2023.045076
IEEE Style
J. MA et al., "Candidate oncogene placenta specific 8 affects cell growth and cell migration in non-small cell lung cancers," BIOCELL , vol. 48, no. 2, pp. 239-252. 2024. https://doi.org/10.32604/biocell.2023.045076



cc Copyright © 2024 The Author(s). Published by Tech Science Press.
This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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