Open Access

REVIEW

Estrogen-related receptor alpha: A novel perspective on skeletal, muscular, and vascular systems

LEI WANG^1,2, ZHI-HANG WANG¹, NIAN-PING CAO¹, BOBO CHEN¹, CHONG-JUN HUANG¹, LEI YANG¹, YE TIAN^1,*

1 Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, China
2 Department of Orthopedics, Fuxin Central Hospital, Fuxin, China

* Corresponding Author: YE TIAN. Email:

(This article belongs to the Special Issue: Subcellular Organelles and Cellular Molecules: Localization, Detection, Prediction, and Diseases)

BIOCELL 2024, 48(2), 191-203. https://doi.org/10.32604/biocell.2023.045349

Received 24 August 2023; Accepted 06 December 2023; Issue published 23 February 2024

Abstract

Estrogen-related receptor alpha can significantly affect cell metabolism and play key regulatory roles in healthy and diseased organisms. ERRα is also related to the onset and progression of various cancer types. ERRα is primarily expressed in metabolically active tissues and regulates the transcription of metabolic genes in such tissues. It coordinates metabolism and energy demand, affects osteoblasts, osteoclasts, and chondrocytes, promotes muscle regeneration, participates in angiogenesis, and regulates cell aging. In this study, the literature related to the identification of ERRα in skeletal, muscular, and vascular systems was reviewed to further elucidate this receptor.

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Keywords

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