Open Access iconOpen Access

COMMENTARY

Biological processes involved in mechanical force transmission in connective tissue: Linking bridges for new therapeutic applications in the rehabilitative field

by AUGUSTO FUSCO1, STEFANO BONOMI2,*, LUCA PADUA1,2

1 UOC Neuroriabilitazione ad Alta Intensità, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, 00168, Italy
2 Department of Geriatrics and Orthopedics, Università Cattolica del Sacro Cuore, Rome, 00168, Italy

* Corresponding Author: STEFANO BONOMI. Email: email

BIOCELL 2025, 49(1), 1-5. https://doi.org/10.32604/biocell.2024.058418

Abstract

Connective tissue is a dynamic structure that reacts to environmental cues to maintain homeostasis, including mechanical properties. Mechanical load influences extracellular matrix (ECM)—cell interactions and modulates cellular behavior. Mechano-regulation processes involve matrix modification and cell activation to preserve tissue function. The ECM remodeling is crucial for force transmission. Cytoskeleton components are involved in force sensing and transmission, affecting cellular adhesion, motility, and gene expression. Proper mechanical loading helps to maintain tissue health, while imbalances may lead to pathological processes. Active and passive movement, including manual mobilization, improves connective tissue elasticity, promotes ECM-cell homeostasis, and reduces fibrosis. In rehabilitation, understanding mechanical-regulation processes is necessary for ameliorating and developing treatments aimed at preserving tissue elasticity and preventing fibrosis. In this commentary, we aim to globally describe the biological processes involved in mechanical force transmission in connective tissue as support for translational studies and clinical applications in the rehabilitation field.

Graphic Abstract

Biological processes involved in mechanical force transmission in connective tissue: Linking bridges for new therapeutic applications in the rehabilitative field

Keywords


Cite This Article

APA Style
FUSCO, A., BONOMI, S., PADUA, L. (2025). Biological processes involved in mechanical force transmission in connective tissue: linking bridges for new therapeutic applications in the rehabilitative field. BIOCELL, 49(1), 1–5. https://doi.org/10.32604/biocell.2024.058418
Vancouver Style
FUSCO A, BONOMI S, PADUA L. Biological processes involved in mechanical force transmission in connective tissue: linking bridges for new therapeutic applications in the rehabilitative field. BIOCELL. 2025;49(1):1–5. https://doi.org/10.32604/biocell.2024.058418
IEEE Style
A. FUSCO, S. BONOMI, and L. PADUA, “Biological processes involved in mechanical force transmission in connective tissue: Linking bridges for new therapeutic applications in the rehabilitative field,” BIOCELL, vol. 49, no. 1, pp. 1–5, 2025. https://doi.org/10.32604/biocell.2024.058418



cc Copyright © 2025 The Author(s). Published by Tech Science Press.
This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
  • 366

    View

  • 138

    Download

  • 0

    Like

Share Link