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Interstage outcomes in single ventricle patients undergoing hybrid stage 1 palliation

Janet M. Simsic, Christina Phelps, Kristin Kirchner, Kirby‐Rose Carpenito, Robin Allen, Holly Miller‐Tate, Karen Texter, Mark Galantowicz

The Heart Center at Nationwide Children’s Hospital, Columbus, Ohio

* Corresponding Author: Janet M Simsic, MD, The Heart Center T2292, Nationwide Children’s Hospital, 700 Children’s Drive, Columbus, OH 43205, USA. Email: email

Congenital Heart Disease 2018, 13(5), 757-763.


Objective: Interstage readmissions are common in infants with single ventricle congenital heart disease undergoing staged surgical palliation. We retrospectively examined readmissions during the interstage period.
Design: Retrospective analysis.
Setting: The Heart Center at Nationwide Children’s Hospital, Columbus, Ohio.
Patients: Newborns undergoing hybrid stage 1 palliation from January 2012 to December 2016 who survived to hospital discharge and were followed at our institution.
Interventions: All patients underwent hybrid stage 1 palliation.
Outcome Measures: Outcomes included (1) reason for interstage readmission; (2) feeding modality during interstage period; (3) major interstage adverse events; and (4) interstage mortality.
Results: Study group comprised 57 patients. Five patients only admitted once during the interstage period for scheduled cardiac catheterization were included in the no readmission group. Therefore, 43 patients (75%) had a total of 87 interstage readmissions. Fourteen patients had 15 major interstage adverse events accounting for 17% of total readmissions. Stroke (n = 1); sepsis (n = 1); pericardial effusion requiring drainage (n = 1); mesenteric ischemia (n = 1); shock (n = 1); and cardiac catheterization requiring intervention (n = 11)— ductal stent balloon angioplasty (n = 3), enlargement of atrial septal defect/stent placement (n = 3), retrograde aortic arch stenosis (n = 4). Thirty‐three readmissions were secondary to gastrointestinal/feeding issues; 15 cyanosis; 15 work of breathing; and 9 asymptomatic patients. Four patients suffered interstage deaths (7%). Five patients (9%) spent >30 days in the hospital during the interstage period. Of the 47 newborns (82%) discharged exclusively orally feeding, 74% remained all orally feeding throughout interstage period. No patient discharged with tube feedings learned to eat during the interstage period.
Conclusion: Interstage readmissions are common in the hybrid patient population. Seventeen percent were secondary to major adverse events. Interstage mortality was 7%. Future studies to identify interventions aimed at decreasing feeding issues and viral bronchiolitis in this tenuous patient population will hopefully improve ­quality outcomes, reduce readmissions, and lessen health care costs.


Cite This Article

Simsic, J. M., Phelps, C., Kirchner, K., Carpenito, K., Allen, R. et al. (2018). Interstage outcomes in single ventricle patients undergoing hybrid stage 1 palliation. Congenital Heart Disease, 13(5), 757–763.

cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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