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Pulsatile Glenn as long‐term palliation for single ventricle physiology patients

Martin A. Chacon‐Portillo1,2, Rodrigo Zea‐Vera1,2, Huirong Zhu3, Heather A. Dickerson4,5, Iki Adachi1,2, Jeffrey S. Heinle1,2, Charles D. Fraser1,2, Carlos M. Mery1,2

1 Division of Congenital Heart Surgery, Texas Children’s Hospital, Houston, Texas
2 Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas
3 Outcomes and Impact Service, Texas Children’s Hospital, Houston, Texas
4 Division of Pediatric Cardiology, Texas Children’s Hospital, Houston, Texas
5 Baylor College of Medicine, Houston, Texas

* Corresponding Author: Martin A. Chacon‐Portillo, MD, Texas Children’s Hospital, 6621 Fannin St, WT19345H, Houston, TX 77030. Email: email

Congenital Heart Disease 2018, 13(6), 927-934.


Objective: There are limited studies analyzing pulsatile Glenn as a long‐term pallia‐ tion strategy for single ventricle patients. This study sought to determine their out‐ comes at a single institution.
Design: A retrospective review was performed.
Setting: Study performed at a single pediatric hospital.
Patients: All single ventricle patients who underwent pulsatile Glenn from 1995 to 2016 were included.
Outcome measures: Pulsatile Glenn failure was defined as takedown, transplant, or death. Further palliation was defined as Fontan, 1.5, or biventricular repair. Risk fac‐ tors were assessed by Cox multivariable competing risk analyses.
Results: Seventy‐eight patients underwent pulsatile Glenn at age 9 months (inter‐ quartile range, 5‐14). In total, 28% had heterotaxy, 18% had a genetic syndrome, and 24% had an abnormal inferior vena cava. There were 3 (4%) perioperative mortalities. Further palliation was performed in 41 (53%) patients with a median time‐to‐pallia‐ tion of 4 years (interquartile range, 3‐5). Pulsatile Glenn failure occurred in 10 (13%) patients with 8 total mortalities. Five‐ and 10‐year transplant‐free survival were 91% and 84%, respectively. At a median follow‐up of 6 years (interquartile range, 2‐8), 27 patients (35%) remained with PG (age 7 years [interquartile range, 3‐11], oxygen sat‐ uration 83% ± 4%). Preoperative moderate‐severe atrioventricular valve regurgita‐ tion (AVVR) (hazard ratio 7.77; 95% confidence interval 1.80‐33.43; P =.005) and higher pulmonary vascular resistance (hazard ratio 2.59; 95% confidence interval 1.08‐6.15; P =.031) were predictors of pulsatile Glenn failure after adjusting for co‐ variates. Reaching further palliation was less likely in patients with preoperative moderate‐severe AVVR (hazard ratio 0.22, 95% confidence interval 0.08‐0.59; P =.002).
Conclusion: Pulsatile Glenn can be an effective tool to be used in challenging circum‐ stances, these patients can have a favorable long‐term prognosis without reducing their suitability for further palliation.


Cite This Article

APA Style
Chacon‐Portillo, M.A., Zea‐Vera, R., Zhu, H., Dickerson, H.A., Adachi, I. et al. (2018). Pulsatile glenn as long‐term palliation for single ventricle physiology patients. Congenital Heart Disease, 13(6), 927-934.
Vancouver Style
Chacon‐Portillo MA, Zea‐Vera R, Zhu H, Dickerson HA, Adachi I, Heinle JS, et al. Pulsatile glenn as long‐term palliation for single ventricle physiology patients. Congeni Heart Dis. 2018;13(6):927-934
IEEE Style
M.A. Chacon‐Portillo et al., "Pulsatile Glenn as long‐term palliation for single ventricle physiology patients," Congeni. Heart Dis., vol. 13, no. 6, pp. 927-934. 2018.

cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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