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Complete atrioventricular canal repair with a decellularized porcine small intestinal submucosa patch

Eliana Al Haddad1*, Damien J. LaPar1*, Jeffrey Dayton2, Elizabeth H. Stephens1, Emile Bacha1

1 Pediatric Cardiac Surgery, Department of Surgery, Morgan Stanley Children’s Hospital, Columbia University Medical Center, New York, New York
2 Division of Pediatric Cardiology, NewYork‐ Presbyterian/Weill Cornell Medical Center, New York, New York

* Corresponding Author: Damien J. LaPar MD, MSc, Assistant Professor of Surgery, Columbia University Vagelos College of Physicians and Surgeons, 3959 Broadway, CHN‐270, New York, NY 10032. Email: email

Congenital Heart Disease 2018, 13(6), 997-1004. https://doi.org/10.1111/chd.12666

Abstract

Background: Congenital heart defects affect nearly 1% of all children born per year in the United States, and complete atrioventricular canal (CAVC) accounts for 2%‐9%. While several patch materials have been used for septal defect closure during CAVC repair, clear superiority of one material over another has yet to be established.
Methods: A retrospective review of clinical outcomes following CAVC repair at Morgan Stanley Children’s Hospital/Columbia University was performed on opera‐ tions conducted from March 2010 to September 2017. Univariate and Kaplan‐Meir survival analyses were utilized to evaluate primary outcomes of interest following CAVC repair in the modern surgical era.
Results: A total of 73 patients were analyzed, with an average operative age of 22 weeks. The majority (71%) of the patients underwent a 2‐patch repair. A CorMatrix patch was used for ventricular septal defect(VSD) closure in 77% of the patients, and/or in 75% of atrial septal defect closures. There was one in‐hospital mortality (1.4%) due to respiratory failure. One patient required a pacemaker. At mid‐term fol‐ low‐up (1.6 years), a total of 7 patients required 8 reoperations due to cardiac‐related indications, including 5 for left atrioventricular valve (LAVV) repair, 1 for LAVV re‐ placement, and 2 isolated residual VSDs.
Conclusion: A standardized repair for CAVC results in excellent outcomes in the cur‐ rent era, with low rates of reoperations. CorMatrix for the closure of CAVC has proven to produce good results with equivalent outcomes to other patch materials. Its ease of use and pliability make it an attractive alternative for consideration.

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Cite This Article

APA Style
Haddad, E.A., LaPar, D.J., Dayton, J., Stephens, E.H., Bacha, E. (2018). Complete atrioventricular canal repair with a decellularized porcine small intestinal submucosa patch. Congenital Heart Disease, 13(6), 997-1004. https://doi.org/10.1111/chd.12666
Vancouver Style
Haddad EA, LaPar DJ, Dayton J, Stephens EH, Bacha E. Complete atrioventricular canal repair with a decellularized porcine small intestinal submucosa patch. Congeni Heart Dis. 2018;13(6):997-1004 https://doi.org/10.1111/chd.12666
IEEE Style
E.A. Haddad, D.J. LaPar, J. Dayton, E.H. Stephens, and E. Bacha "Complete atrioventricular canal repair with a decellularized porcine small intestinal submucosa patch," Congeni. Heart Dis., vol. 13, no. 6, pp. 997-1004. 2018. https://doi.org/10.1111/chd.12666



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