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ARTICLE

Mai Ishiwata^1,2, Kohei Ishibashi^1,*, Yoshiaki Kato³, Heima Sakaguchi³, Toshihiro Nakamura¹, Satoshi Oka¹, Yuichiro Miyazaki¹, Akinori Wakamiya¹, Nobuhiko Ueda¹, Kenzaburo Nakajima¹, Tsukasa Kamakura¹, Mitsuru Wada¹, Yuko Inoue¹, Koji Miyamoto¹, Takeshi Aiba¹, Norihiko Takeda², Kengo Kusano¹
Congenital Heart Disease, Vol.20, No.3, pp. 273-286, 2025, DOI:10.32604/chd.2025.067716 - 11 July 2025
Abstract Background: Ventricular arrhythmia is a common cause of mortality in adult congenital heart disease (ACHD). The beneficial effects of implantable cardioverter-defibrillators (ICD) in patients with ACHD have been demonstrated; however, evidence on this topic remains insufficient. This study aimed to assess the long-term outcomes after ICD implantation in the ACHD population. Methods: We retrospectively reviewed 35 consecutive patients with ACHD who underwent ICD implantation between December 2012 and August 2022. ICD implantation was classified as primary or secondary prevention. The long-term outcomes, including all-cause mortality, appropriate and inappropriate ICD therapy, and complications related to ICD implantation, were… More >

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REVIEW

Honghao Fu^#, Zhangwei Wang^#, Shoujun Li^*
Congenital Heart Disease, Vol.20, No.3, pp. 287-303, 2025, DOI:10.32604/chd.2025.067619 - 11 July 2025
（This article belongs to the Special Issue: Novel Methods and Techniques for the Management of Congenital Heart Disease)
Abstract Congenital heart disease (CHD) stands as the most common cardiovascular disorder among children, exerting a profound impact on the growth, development, and quality of life of the affected pediatric population. The modified Fontan procedure, the total cavopulmonary connection (TCPC), has become a pivotal palliative or definitive surgical method for treating complex CHD cases, including single ventricle and tricuspid valve atresia. Through staged surgical processes, this technique directly diverts vena cava blood into the pulmonary artery, thus improving the patient’s oxygenation status. Despite the initial success of the Fontan circulation in providing a means for survival More >

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REVIEW

Wilhelm Mistiaen^*
Congenital Heart Disease, Vol.20, No.3, pp. 305-323, 2025, DOI:10.32604/chd.2025.064675 - 11 July 2025
Abstract The presence of a bicuspid aortic valve (BAV) is the most common congenital heart anomaly, which can remain asymptomatic for decades, if it is not a part of a syndrome, such as Turner syndrome or genetic connective tissue disorders. There are several classifications for BAV, each with its advantages and drawbacks. The condition can lead to valvular malfunction such as regurgitation and stenosis, but is often associated with dilatation of the aortic root, the ascending aorta, the aortic arch, or a combination. Altered flow patterns due to the valve dysfunction as well as the breakdown… More >

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592

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REVIEW

Lily M. Landry^1,*, Christopher L. Jenks²
Congenital Heart Disease, Vol.20, No.3, pp. 325-339, 2025, DOI:10.32604/chd.2025.066142 - 11 July 2025
Abstract Pulmonary hypertension associated with congenital heart disease represents a significant challenge for clinicians due to its complex pathophysiology and diverse presentation. This patient population exhibits a broad spectrum of anatomical and hemodynamic abnormalities, with congenital heart disease-associated pulmonary arterial hypertension (PAH-CHD) comprising a significant proportion of pediatric pulmonary hypertension (PH) cases. Although progress in diagnostic methods and treatment options has been made, PH continues to be a major contributor to illness and death among affected pediatric patients, especially when diagnosis or treatment is postponed. This review aims to equip non-specialist clinicians with a better understanding More >

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CASE REPORT

Ji Lam Leong, Sivakumar Sivalingam^*
Congenital Heart Disease, Vol.20, No.3, pp. 341-346, 2025, DOI:10.32604/chd.2025.066461 - 11 July 2025
Abstract Left atrial aneurysm is an exceptionally rare condition, particularly in the pediatric population, and even more so as a sequela of bacterial pericarditis. We present the case of a 16-month-old girl who developed a left atrial aneurysm following isolated Staphylococcus aureus pericarditis. She initially presented in decompensated shock and was later diagnosed with constrictive pericarditis. Despite undergoing pericardiectomy, she subsequently developed a left atrial aneurysm, necessitating surgical closure. This case highlights the aggressive nature of bacterial pericarditis and its potential to cause rare structural cardiac complications. More >

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602

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ARTICLE

Guozhen Wang^1,2, Yong An^1,2,*
Congenital Heart Disease, Vol.20, No.3, pp. 347-355, 2025, DOI:10.32604/chd.2025.065354 - 11 July 2025
Abstract Background: Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare congenital anomalous coronary artery origin disorder. Objective: We sought to summarize the clinical experience and prognostic characteristics of surgical treatment of ALCAPA. Methods: We retrospectively analyzed clinical information on patients who had ALCAPA and underwent surgery at our center from February 2016 to October 2023. Results: This comparative study of 23 ALCAPA patients (9 infants <1 year; 14 children >1 year) demonstrated significant age-dependent outcomes. Infant patients exhibited markedly prolonged mechanical ventilation (183 ± 105.6 vs. 48.5 ± 62.2 min, p =… More >

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561

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ARTICLE

Yushen Fang¹, Zechen Li¹, Jiahong Li¹, Kaiyu Wang¹, Gang Xu¹, Shusheng Wen^1,2, Jimei Chen^1,2, Jian Zhuang^1,2, Haiyun Yuan^1,2,*, Xiaobing Liu^1,2,*
Congenital Heart Disease, Vol.20, No.3, pp. 357-368, 2025, DOI:10.32604/chd.2025.066817 - 11 July 2025
（This article belongs to the Special Issue: Novel Methods and Techniques for the Management of Congenital Heart Disease)
Abstract Background: Totally thoracoscopic surgery (TTS) and right lateral thoracotomy (RLT) are both extensively utilized in the surgical repair for atrial septal defect (ASD). However, RLT is generally considered in low-weight pediatric patients as a result of restricted surgical exposure. This study aims to introduce an RLT approach for ASD repair in adults and compare its clinical outcomes with TTS. Methods: We conducted a retrospective analysis of the clinical data of 23 adult patients who underwent ASD repair at Guangdong Provincial People’s Hospital between June and October 2024. Patients were divided into two groups based on the… More >

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597

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REVIEW

Juliana Assis Alves¹, Mayra Martins Melo¹, Lorenza Machado Teixeira², Nathalie Jeanne Bravo-Valenzuela³, Edward Araujo Júnior^1,2,*
Congenital Heart Disease, Vol.20, No.3, pp. 369-381, 2025, DOI:10.32604/chd.2025.066358 - 11 July 2025
Abstract Congenital heart disease (CHD) is the most common congenital anomaly and a major cause of death among fetal malformations, but prenatal diagnosis is considered to be low. The development of artificial intelligence (AI) in fetal echocardiography has made it possible to automate and standardise the examination, improving the variation in CHD detection rates between different regions and reducing the reliance on operator experience. AI includes any computer program (algorithms and models) that mimics human logic and intelligence, and its use in fetal echocardiography is mainly to acquire and optimise images, perform automatic measurements, identify discrepant More >

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664

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ARTICLE

Jingdong Qi^1,#, Fei Zhang^1,#, Xia Zhang^2,*
Congenital Heart Disease, Vol.20, No.3, pp. 383-400, 2025, DOI:10.32604/chd.2025.064790 - 11 July 2025
Abstract Background: Congenital heart disease (CHD) remains a significant global health concern, with considerable heterogeneity across age groups, genders, and regions. Objective: This study aimed to investigate the global epidemiological patterns, inequalities, and socio-demographic determinants of CHD burden from 1990 to 2021 to inform targeted interventions. Methods: This study aimed to investigate the global epidemiological patterns, inequalities, and socio-demographic determinants of CHD burden from 1990 to 2021 to inform targeted interventions. Results: CHD burden increased with age, peaking among individuals aged 70 years and older. This does not reflect new-onset disease, but rather the accumulation of late diagnoses,… More >

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CORRECTION

Xiaofeng Wang^1,#, Xingwei Chen^2,#, Shilin Wang¹, Xia Li¹, Zhongyuan Lu¹, Wenlong Wang¹, Xu Wang^1,*
Congenital Heart Disease, Vol.20, No.3, pp. 401-402, 2025, DOI:10.32604/chd.2025.070042 - 11 July 2025
Abstract This article has no abstract. More >

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