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Numerical Simulations of One-Directional Fractional Pharmacokinetics Model

Nursyazwani Mohamad Noor1, Siti Ainor Mohd Yatim1,*, Nur Intan Raihana Ruhaiyem2

1 School of Distance Education, Universiti Sains Malaysia, USM Penang, Penang, 11800, Malaysia
2 School of Computer Science, Universiti Sains Malaysia, USM Penang, Penang, 11800, Malaysia

* Corresponding Author: Siti Ainor Mohd Yatim. Email: email

Computers, Materials & Continua 2022, 73(3), 4923-4934.


In this paper, we present a three-compartment of pharmacokinetics model with irreversible rate constants. The compartment consists of arterial blood, tissues and venous blood. Fick’s principle and the law of mass action were used to develop the model based on the diffusion process. The model is modified into a fractional pharmacokinetics model with the sense of Caputo derivative. The existence and uniqueness of the model are investigated and the positivity of the model is established. The behaviour of the model is investigated by implementing numerical algorithms for the numerical solution of the system of fractional differential equations. MATLAB software is used to plot the graphs for illustrating the variation of drug concentration concerning time. Therefore, the numerical simulations of the model are presented for different values of α which verified the theoretical analysis. Besides, we also observed the pattern of the simulations at the three-compartment of the model by using different values of initial conditions.


Cite This Article

APA Style
Noor, N.M., Yatim, S.A.M., Ruhaiyem, N.I.R. (2022). Numerical simulations of one-directional fractional pharmacokinetics model. Computers, Materials & Continua, 73(3), 4923-4934.
Vancouver Style
Noor NM, Yatim SAM, Ruhaiyem NIR. Numerical simulations of one-directional fractional pharmacokinetics model. Comput Mater Contin. 2022;73(3):4923-4934
IEEE Style
N.M. Noor, S.A.M. Yatim, and N.I.R. Ruhaiyem "Numerical Simulations of One-Directional Fractional Pharmacokinetics Model," Comput. Mater. Contin., vol. 73, no. 3, pp. 4923-4934. 2022.

cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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