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Oxygen Transport in Tissue Engineering Systems: Cartilage and Myocardium

B. Obradovic1, M. Radisic2, G. Vunjak-Novakovic3

Faculty of Technology and Metallurgy, Belgrade University, Belgrade, Serbia
University of Toronto, Toronto, Ontario, Canada
Columbia University, New York, NY, U.S.A.

Fluid Dynamics & Materials Processing 2007, 3(3), 189-202.


Efficient transport of oxygen is one of the main requirements in tissue engineering systems in order to avoid cell death in the inner tissue regions and support uniform tissue regeneration. In this paper, we review approaches to design of tissue engineering systems with adequate oxygen delivery for cultivation of cartilage and myocardium, two distinctly different tissue types with respect to the tissue structure and oxygen requirements. Mathematical modeling was used to support experimental results and predict oxygen transport within the cultivated tissues and correlate it to the cell response and tissue properties.


Cite This Article

Obradovic, B., Radisic, M., Vunjak-Novakovic, G. (2007). Oxygen Transport in Tissue Engineering Systems: Cartilage and Myocardium. FDMP-Fluid Dynamics & Materials Processing, 3(3), 189–202.

This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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