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ARTICLE
Chitosan/PVA Films and Silver Nanoparticle Impregnated Nanofibrous Dressings for Evaluation of their Wound Healing Efficacy in Wistar Albino Rat Model
SOBHA KOTA*, RATNAKUMARI ANANTHA, VAYUNANDANA RAO GOVADA, PRADEEP DUMPALA
RVR and JC College of Engineering, Department of Chemical Engineering,
Guntur, Andhra Pradesh, India
* Corresponding Author: e-mail:
Journal of Polymer Materials 2023, 40(3-4), 285-303. https://doi.org/10.32381/JPM.2023.40.3-4.10
Abstract
The exoskeleton of marine shrimp contains a natural, biocompatible polymer chitin, which is
dumped as a waste. The study proposes the sustainable single-pot-extraction of chitosan from
the waste and its use in the fabrication of wound-dressings, and thus leverage its piezoelectric,
antioxidant, hypoglycaemic and medicinal properties in wound-healing. The Fourier transform
infrared spectrum revealed that marine chitosan contains functional groups with N-O, O-H, and
CO stretching. Scanning electron micrographs demonstrated the spherical and mesoporous
structures of the extracted chitosan. X-ray diffraction analysis showed a semi-crystalline phase
of chitosan particles with a mean size of 28.9 nm. The film prepared with marine shrimp chitosanpolyvinyl alcohol (PVA) composite, and used as a wound dressing exhibited significant wound
healing properties with a regeneration efficiency of 78% in 8 days in Wistar albino rats. The
wound healing efficiency was enhanced by the addition of cost effective, non-toxic/environmentally
friendly silver nanoparticles (AgNPs) synthesized from Rumex acetosa (sorrel) plant extracts
and electrospinning of the nanofibrous composites of chitosan/PVA/AgNPs with high
antibacterial, antioxidant and wound healing capacity of 96% in 8 days. Thus, the current study
supports the use of a natural piezoelectric chitosan polymer as a wound dressing material,
either in film or nanofiber, for normal as well as diabetic wounds.
Keywords
Cite This Article
APA Style
KOTA, S., ANANTHA, R., GOVADA, V.R., DUMPALA, P. (2023). Chitosan/pva films and silver nanoparticle impregnated nanofibrous dressings for evaluation of their wound healing efficacy in wistar albino rat model. Journal of Polymer Materials, 40(3-4), 285-303. https://doi.org/10.32381/JPM.2023.40.3-4.10
Vancouver Style
KOTA S, ANANTHA R, GOVADA VR, DUMPALA P. Chitosan/pva films and silver nanoparticle impregnated nanofibrous dressings for evaluation of their wound healing efficacy in wistar albino rat model. J Polym Materials . 2023;40(3-4):285-303 https://doi.org/10.32381/JPM.2023.40.3-4.10
IEEE Style
S. KOTA, R. ANANTHA, V.R. GOVADA, and P. DUMPALA "Chitosan/PVA Films and Silver Nanoparticle Impregnated Nanofibrous Dressings for Evaluation of their Wound Healing Efficacy in Wistar Albino Rat Model," J. Polym. Materials , vol. 40, no. 3-4, pp. 285-303. 2023. https://doi.org/10.32381/JPM.2023.40.3-4.10