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A Promising Wound Dressing from Regenerated Silk Fibroin Sponge with Sustain-ed Release of Silver Nanoparticles

Yang Li#, Xiaoying Zha#, Xingliang Xiong, Yan Zhang, Ying Feng, Haojiang Xie, Linqing Zhang, Qifeng Jiang*

Department of Medical Information, Chongqing Medical University, Chongqing, 400016, China
# The authors contribute equally

* Corresponding Author: Qifeng Jiang. Email: email

Journal of Renewable Materials 2021, 9(2), 295-310.


A silk fibroin (SF) spongy wound dressing incorporated with silver nanoparticles (Ag-NPs) was developed for biomedical applications. Ag-NPs were efficiently synthesized in situ via ultra violet (UV) with AgNO3 as precursor and silk fibroin as reducing and protecting agent, respectively. After lyophilization, the formed silk fibroin spongy wound dressing (SFWD) exhibited polyporous morphology and inner lamellae structures, with uniform dispersion of Ag-NPs. The porous structure provided SFWD with the ability to absorb tissue exudatealmost 6 times of its own weight, which could guarantee the sustained release of Ag-NPs. By methanol treatment, SFWD showed much improved mechanical properties and more stable to protease XIV. The cyto-compatibility of SFWD was supported by normal adherence and proliferation of NIH3T3 fibroblasts in sponges extracting culture medium. More important, the SFWD showed significant growth inhibition in both plate culture assays and bacterial suspension assays, with Grampositive (Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa and Escherichia coli). In a cutaneous excisional mouse model, the average healing rates of SFWD was significantly higher than control and commercial bandages. The hematoxylin-eosin (HE) staining results of the wound section also showed that SFWD could recruit more cells and promote tissue formation on the wound edges.


Cite This Article

Li, Y., Zha, X., Xiong, X., Zhang, Y., Feng, Y. et al. (2021). A Promising Wound Dressing from Regenerated Silk Fibroin Sponge with Sustain-ed Release of Silver Nanoparticles. Journal of Renewable Materials, 9(2), 295–310.


cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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