Open Access

ARTICLE

Comparison of Right Ventricle Morphological and Mechanical Characteristics for Healthy and Patients with Tetralogy of Fallot: An In Vivo MRI-Based Modeling Study

Dalin Tang^1,*,2, Heng Zuo^2,*, Chun Yang², Zheyang Wu², Xueying Huang³, Rahul H. Rathod⁴, Alexander Tang⁴, Kristen L. Billiar⁵, Tal Geva⁴
1 School of Biological Science & Medical Engineering, Southeast University, Nanjing, 210096, China.
2 Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609.
3 School of Mathematical Sciences, Xiamen University, Xiamen, Fujian 361005, China.
4 Department of Cardiology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA 02115 USA.
5 Department of Biomedical Engineering, Worcester Polytechnic Institute, MA 01609, USA.
* Co-first authors
Corresponding author: Dalin Tang, , 508-845-1575, fax: 508-831-5824.

Molecular & Cellular Biomechanics 2017, 14(3), 137-151. https://doi.org/10.3970/mcb.2017.014.137

Abstract

Patients with repaired tetralogy of Fallot (TOF) account for the majority of cases with late onset right ventricle failure. Comparing TOF patients with healthy people may provide information to address this challenge. Cardiac magnetic resonance (CMR) data were obtained from 16 TOF patients (patient group, PG) and 6 healthy volunteers (healthy group, HG). At begin-of-ejection, better patient group (n=5, BPG) stress was very close to HG stress (54.7±38.4 kPa vs. 51.2±55.7 kPa, p=0.6889) while worse patient group (n=11, WPG) stress was 84% higher than HG stress (p=0.0418). Stress may be used as an indicator to differentiate BPG patients from WPG patients, with further validations.

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Keywords

Heart modeling, cardiac mechanics, normal ventricle, right ventricle, tetralogy of Fallot.

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