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Theoretical Prediction and Experimental Testing of Mechanical Properties for 3D Printed Silk Fibroin-Type II Collagen Scaffolds for Cartilage Regeneration

Lilan Gao1,2,*, Qingxian Yuan1,2, Ruixin Li3,*, Lei Chen1,2, Chunqiu Zhang1,2, Xizheng Zhang1,2

Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control, School of Mechanical Engineering, Tianjin University of Technology, Tianjin 30000, China.
National Demonstration Center for Experimental Mechanical and Electrical Engineering Education (Tianjin University of Technology), Tianjin300000, China.
Hospital of Stomatolgy, NanKai University, Tianjin300000, China .

* Corresponding author: Lilan Gao. Email: ; Ruixin Li. Email: .

Molecular & Cellular Biomechanics 2018, 15(2), 85-98. 10.3970/mcb.2018.00329


Silk fibroin-typeⅡcollagen scaffold was made by 3D printing technique and freeze-drying method, and its mechanical properties were studied by experiments and theoretical prediction. The results show that the three-dimensional silk fibroin-typeⅡ collagen scaffold has good porosity and water absorption, which is (89.3%+3.26%) and (824.09%+93.05%), respectively. With the given strain value, the stress of scaffold decreases rapidly firstly and then tends to be stable during the stress relaxation. Both initial and instantaneous stresses increase with increase of applied strain value. The creep strains of scaffold with different stress levels show the two stages: the rapidly increasing stage and the second stable stage. It is noted that the scaffold with compressive stress of less than 35 kPa can recover when the compressive stress is removed. However when the compressive stress is higher than 50 kPa, the scaffold is damaged and its structure is destroyed. Not only the compressive property but tensile property of scaffold are dependent on the applied displacement rate or strain rate. Its compressive elastic modulus and tensile modulus increase with increase of strain rate or displacement rate. The nonlinear relaxation model and creep model were constructed respectively and applied to predict the stress relaxation behavior and creep behavior of scaffold. It is found that there are good agreements between the experimental data and predictions, which mean that the built theoretical model can predict the mechanical behavior of scaffold.


Cite This Article

Gao, L., Yuan, Q., Li, R., Chen, L., Zhang, C. et al. (2018). Theoretical Prediction and Experimental Testing of Mechanical Properties for 3D Printed Silk Fibroin-Type II Collagen Scaffolds for Cartilage Regeneration. Molecular & Cellular Biomechanics, 15(2), 85–98.

This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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