Open Access

ARTICLE

Efficiently and Conveniently Heparin/ PEG-PCL Core-Shell Microcarriers Fabrication and Optimization via Coaxial-Electrospraying

Ying Mao¹, Chaojing Li¹, Peng Ge¹, Fujun Wang^1,*, Lu Wang^1,*

1 Key Laboratory of Textile Technology, Ministry of Education, College of textiles, Donghua University, Songjiang District, Shanghai, 201620, China.

* Corresponding Author: Fujun Wang. E-mail: ;
   Lu Wang. E-mail: .

Molecular & Cellular Biomechanics 2018, 15(3), 143-154. https://doi.org/ 10.3970/mcb.2018.03987

Abstract

Heparin/ PEG-PCL core-shell microcarriers were fabricated in one-step via coaxial-electrospraying technology. Optimization of the coaxial-electrospraying processing is by controlling the PEG-PCL concentration, applied voltage, receiving distance, and feed rate. The influence of the electrospray parameters on microsphere morphology was studied by optical microscopy and scanning electron microscopy. The functional groups and components of the electrosprayed microspheres were characterized by Fourier transform infrared spectroscopy (FTIR). Transmission electron microscope (TEM) observation proved the core-shell structure of heparin-loaded PEG-PCL microspheres. Drug loading and releasing study demonstrated that PEG-PCL concentration could control the encapsulation efficiency and releasing activity of the heparin in the microspheres. The hemocompatibility assays indicated that the anticoagulant property of PCL membranes improved markedly, when the surface modified with heparin-loaded PEG-PCL microspheres.

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Keywords

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