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Optical-CT Dual-Modality Mapping Base on DRR Registration

Qingyang Zang1, Dongsheng Li1, Chunxiao Chen1,*, Jianfei Li1

1 Department of Biomedical Engineering, Nanjing University of Aeronautics & Astronautics, Nanjing, 211106, China.

* Corresponding Author: Chunxiao Chen. Email: .

Molecular & Cellular Biomechanics 2019, 16(4), 253-263.


Optical-CT dual-modality imaging requires the mapping between 2D fluorescence images and 3D body surface light flux. In this paper, we proposed an optical-CT dual-modality image mapping algorithm based on the Digitally Reconstructed Radiography (DRR) registration. In the process of registration, a series of DRR images were computed from CT data using the ray casting algorithm. Then, the improved HMNI similarity strategy based on Hausdorff distance was used to complete the registration of the white-light optical images and DRR virtual images. According to the corresponding relationship obtained by the image registration and the Lambert’s cosine law based on the pin-hole imaging model, the 3D light intensity distribution on the surface of the object could be solved. The feasibility and effectiveness of the mapping algorithm are verified by the irregular phantom and mouse experiments.


Cite This Article

Zang, Q., Li, D., Chen, C., Li, J. (2019). Optical-CT Dual-Modality Mapping Base on DRR Registration. Molecular & Cellular Biomechanics, 16(4), 253–263.

This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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