Open Access

ABSTRACT

Systems Modeling of Cardiomyocyte Mechanobiology

Philip M. Tan¹, Kyle S. Buchholz², Shulin Cao², Yasser Aboelkassem², Jeffrey H. Omens², Andrew D. McCulloch^2,*, Jeffrey J. Saucerman¹

1 Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA.
2 Departments of Bioengineering and Medicine, University of California San Diego, La Jolla, CA, USA.
* Corresponding Author: Andrew D. McCulloch. Email: amccculloch@ucsd.edu.

Molecular & Cellular Biomechanics 2019, 16(Suppl.1), 1-3. https://doi.org/10.32604/mcb.2019.05693

Abstract

In this article, we summarize our systems model of cardiomyocyte mechano-signaling published in PLoS Computational Biology and discuss new approaches to extending these models to predict cardiac myocyte gene expression in response to stretch.

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Keywords

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