• Journal Logo

Table of Content

Open Access iconOpen Access

ABSTRACT

The Role of P53 in Transdifferentiation of EPCs into Smooth Muscle Cells Induced by Oscillatory Shear Stress

Yu Gao1, Meiyue Wang1, Yanting He1, Lanlan Li1, Xiaodong Cui1, Min Cheng1,*, Xiaoyun Zhang1,*

1 Clinical Medical College, Weifang Medical University, Weifang, 261053, China.
* Corresponding Authors: Zhang Xiaoyun. Email: xiaoyun.zhang@126.com.
  Min Cheng. Email: mincheng@wfmc.edu.cn.

Molecular & Cellular Biomechanics 2019, 16(Suppl.1), 93-93. https://doi.org/10.32604/mcb.2019.05758

Abstract

This study examines the effects of P53 in transdifferentiation of endothelial progenitor cells (EPCs) into smooth muscle cells induced by oscillatory shear stress. Endothelial progenitor cells (EPCs) were planted on slide and treated with 4 dyne/cm2 oscillatory shear stress (OSS). Results showed that the expression P53 was decreased time dependent after OSS. The OSS also attenuated the endothelial cells marker vWF and CD31 expression but enhanced the marker of smooth muscle cell α-SMA and SM22 expression in EPCs. After EPCs were pretreated with P53 agonist, the changes of angiogenesis in vitro were detected by matrix gel, and the expressions of alpha-SMA and SM22 were detected by Western blot. The results showed that simple oscillatory shear stress could decrease but P53 agonist could improve the ability of angiogenesis on EPCs, and down-regulate the expression of α-SMA and SM22. From the above results, we speculate that P53 may play a role in the transdifferentiation of EPCs into smooth muscle cells induced by OSS.

Keywords


Cite This Article

APA Style
Gao, Y., Wang, M., He, Y., Li, L., Cui, X. et al. (2019). The role of P53 in transdifferentiation of epcs into smooth muscle cells induced by oscillatory shear stress . Molecular & Cellular Biomechanics, 16(Suppl.1), 93-93. https://doi.org/10.32604/mcb.2019.05758
Vancouver Style
Gao Y, Wang M, He Y, Li L, Cui X, Cheng M, et al. The role of P53 in transdifferentiation of epcs into smooth muscle cells induced by oscillatory shear stress . Mol Cellular Biomechanics . 2019;16(Suppl.1):93-93 https://doi.org/10.32604/mcb.2019.05758
IEEE Style
Y. Gao et al., "The Role of P53 in Transdifferentiation of EPCs into Smooth Muscle Cells Induced by Oscillatory Shear Stress ," Mol. Cellular Biomechanics , vol. 16, no. Suppl.1, pp. 93-93. 2019. https://doi.org/10.32604/mcb.2019.05758



cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
  • 1883

    View

  • 913

    Download

  • 0

    Like

Share Link