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Effect of Dextran 500 on Radial Migration of Erythrocytes in Postcapillary Venules at Low Flow Rates

Sangho Kim∗,†, Peng Kai Ong*, Paul C. Johnson

Division of Bioengineering, National University of Singapore, Singapore
Department of Surgery, National University of Singapore, Singapore
Corresponding author. Department of Bioengineering, University of California San Diego, La Jolla, CA 92093-0412; Phone: (858) 534-5686; Fax: (858) 822-4830; E-mail:

Molecular & Cellular Biomechanics 2009, 6(2), 83-92.


Recently, we reported that collision efficiency (fraction of total collisions that result in the formation of aggregates) between red blood cells was an important factor in the formation of aggregates in postcapillary venules. In the present study, we focus on how high molecular weight dextran influences the overall radial migration trend of red blood cells in the postcapillary venule along a longitudinal distance of 50 μm from the bifurcation which would in turn affect collision behavior of these cells. A radial migration index, which defines the extent of radial migration of individual cells relative to the vessel center, was found to have a larger magnitude after infusion of dextran (1.9 ± 2.73) compared to that before dextran infusion (1.48 ± 3.89). This implied that dextran-induced aggregation might provide an external force to actively move cells towards the centerline of the vessel, which could contribute to the greater number of red blood cells participating in collision (16% increase) and aggregate formation. Further analysis of the collision behavior of individual red blood cells revealed that collision frequencies of individual cells decreased from a wide range (1 to 14) to a narrow range (1 to 5) after dextran treatment, indicating the alteration of collision behavior of red blood cells by the presence of aggregates along the flow stream.


Cite This Article

Kim, S., Ong, P. K., Johnson, P. C. (2009). Effect of Dextran 500 on Radial Migration of Erythrocytes in Postcapillary Venules at Low Flow Rates. Molecular & Cellular Biomechanics, 6(2), 83–92.

This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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