Table of Content

Open Access

ARTICLE

On p21 Tracking Property in Cancer Cell Unravelled Bio-Digitally in silico. Are Apoptosis Principles Universal?

R. M. Ardito Marretta∗,†, G. Barbaraci
Department of Structural, Aerospace Engineering and Geotechnics, University of Palermo, Viale delle Scienze, Block 8, 90128, Palermo, Italy
Corresponding author. Tel.: +39-91-6459912; Fax: +39-91-485439; Email: romario@unipa.it
Department of Mechanical Engineering, University of Palermo, Viale delle Scienze, 90128, Palermo, Italy

Molecular & Cellular Biomechanics 2010, 7(3), 135-164. https://doi.org/10.3970/mcb.2010.007.135

Abstract

Upon severe DNA damage, p21 acts in a dual mode; on the one hand, it inhibits the cyclin-CDK complex for arresting the G2/M transition and on the other hand, it indirectly becomes an apoptotic factor by activating - in sequence - the retinoblastoma protein, E2F1 and APAF1 expressions. But, in a cancer cells proliferation, the mechanisms of, and participants in, the apoptosis failure remain unclear. Since the p21/p53/Mdm2 proteins network normally involves a digital response in a cancer cell, through an original design of a cell signalling-protein simulator, we demonstrate,in silico, that apoptosis phase instability is fully reciprocated by p21mRNA irregular dynamics which operates according to a "tracking memory" principle. We show p21mRNA paradoxically ceases to act in concert with specific target genes and becomes an underlying accomplice of cancer proliferation. Here, we also identify the mechanisms for allowing the cancer cell to re-enter inside a steady stable apoptosis phase.

Keywords

cancer cell apoptosis, digital cell biology, protein signalling, protein networks

Cite This Article

M., R., Barbaraci, G. (2010). On p21 Tracking Property in Cancer Cell Unravelled Bio-Digitally in silico. Are Apoptosis Principles Universal?. Molecular & Cellular Biomechanics, 7(3), 135–164.



This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
  • 992

    View

  • 784

    Download

  • 0

    Like

Share Link

WeChat scan