Analysis of the Effects of Different Surgical Procedures for the Treatment of Thyroid Cancer on the Expression Levels of IL-17, IL-35, and SIL-2R and the Prognostic Factors
  • Chuanwei Xu1, Renju Ding2, Chuanping Xu3,*
1 Department of Breast and Thyroid Surgery, Linyi Hospital of Traditional Chinese Medicine, Linyi, China
2 The First Department of Lung Disease, Linyi Hospital of Traditional Chinese Medicine, Linyi, China
3 Linyi Tumor Hospital, Linyi, China
* Corresponding Author: Chuanping Xu. Email: Xcw3696@163.com
Abstract
To analyze the effects of different surgical procedures for the treatment of thyroid cancer on the expression levels of serum interleukin-17 (IL-17), IL-35, soluble interleukin-2 receptor (SIL-2R), and the prognostic factors. Seventy-eight patients with differentiated thyroid cancer were selected and grouped as control group (CG) (n = 39, underwent subtotal thyroidectomy) and observation group (OG) (n = 39, underwent total thyroidectomy). The serum IL-17, IL-35, and SIL- 2R expression levels; the incidence of complications; and the differentiated thyroid carcinoma (DTC) relapse rate were compared between the two groups. The serum IL-17 and SIL-2R levels were lower in the OG than in the CG on the third, fifth, and seventh days after the operation, but the IL-35 levels were higher than those in the CG (p < 0.05). There were no cases of relapse in the OG, and the DTC relapse rate was lower than that of the CG (15.38%) (p < 0.05). The differences in age; lesion diameter; serum IL-17, IL-35, and SIL-2R expression levels; AJCC thyroid cancer stage; and disease type between DTC relapse and relapse-free patients were statistically significant (p < 0.05). Older age; higher IL-17, lower IL- 35, and higher SIL-2R expression levels; higher AJCC thyroid cancer stage; and disease type were positively correlated with DTC relapse (p < 0.05). Compared with subtotal thyroidectomy, total thyroidectomy for the treatment of thyroid cancer has greater advantages in improving immune inflammation and reducing the relapse rate. Older age; higher IL-17, lower IL-35, and higher SIL-2R expression levels; higher AJCC thyroid cancer stage; and disease type are independent risk factors affecting thyroid cancer relapse after surgery. These findings can reference the selection of clinical surgery procedures in the treatment of thyroid cancer.
Keywords
Thyroid cancer; SIL-2R; prognostic; IL-17; different surgical procedures; IL-35
Cite This Article
Xu, C., Ding, R., Xu, C. (2020). Analysis of the Effects of Different Surgical Procedures for the Treatment of Thyroid Cancer on the Expression Levels of IL-17, IL-35, and SIL-2R and the Prognostic Factors. Oncologie, 22(1), 43–51.
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