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Circulating circRNAs as Potential Biomarkers for Cancers

Ruoyu Liu1,#, Yuhao Hu1,#, Jing Xu2, Aiting Cai1, Anqi Wu1, Lin Chen3, Weihua Cai3, Deping Dong4, Henggui Xu5,*, Feng Wang1,*
1 Department of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong, China
2 Department of Laboratory Medicine, School of Public Health, Nantong University, Nantong, China
3 Department of Gastroenterology and Laboratory Medicine, Nantong Third Hospital Affiliated to Nantong University, Nantong, China
4 Department of Laboratory Medicine, Hai’an People’s Hospital Affiliated to Nantong University, Nantong, China
5 Department of Laboratory Medicine, Taizhou Jiangyan Hospital of Traditional Chinese Medicine, Taizhou, China
* Corresponding Authors: Henggui Xu. Email: ; Feng Wang. Email:

Oncologie 2021, 23(3), 303-320.

Received 30 July 2021; Accepted 03 September 2021; Issue published 26 September 2021


Cancers are diseases with a high mortality rate worldwide. In order to better diagnose and improve the survival rate, many studies have been conducted. In recent years, the role of non-coding RNAs in cancers has been confirmed, and circular RNAs (circRNAs) have attracted much attention. CircRNAs are involved in the occurrence and development of cancers with high stability. Experiments have shown that they can exist stably in peripheral blood. Therefore, the expression of circulating circRNAs can be detected to help diagnose cancers and reflect tumor progression. In this review, we summarized the role of circulating circRNAs in cancers and discussed their potential as biomarkers.


Circulating circRNAs; plasma; serum; diagnosis biomarkers; cancers

Cite This Article

Liu, R., Hu, Y., Xu, J., Cai, A., Wu, A. et al. (2021). Circulating circRNAs as Potential Biomarkers for Cancers. Oncologie, 23(3), 303–320.

This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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